Journal of Molecular Evolution

, Volume 7, Issue 2, pp 151–157 | Cite as

The prebiotic synthesis of deoxythymidine oligonucleotides

III. Acid Salt Reactions
  • Daniel G. Odom
  • John T. Brady
  • John Oro


A reaction shown to oligomerize nucleotides under possible prebiotic conditions has been made more plausible by the finding that the reaction can proceed at initial neutral pH in the presence of acid salts or NH4Cl.

Key words

Prebiotic Sythesis Nucleotides Oligonucleotides 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bada, J.L., Miller, S.L. (1968). Science 159, 423–425Google Scholar
  2. Khorana, H.G., Vizsolyi, J.P., Ralph, R.K. (1962). J.Am.Chem.Soc. 84, 414–418Google Scholar
  3. Miller, S.L., Orgel, L.E. (1974). The origins of life on the earth, p. 40. Englewood Cliffs: Prentice-HallGoogle Scholar
  4. Odom, D.G., Brady, J.T. (1975). J.Mol.Evol. 6, 199Google Scholar
  5. Oró, J. (1963). Ann.N.Y.A.S. 108, 464–481Google Scholar
  6. Sillern, L.G. (1967). Science 156, 1189–1197Google Scholar
  7. Stephen-Sherwood, E., Odom, D.G., Oro, J. (1974). J.Mol.Evol. 3, 323–330Google Scholar
  8. Tener, G.M., Khorana, H.G., Markham, R., Pol, E.H. (1958). J.Am.Chem.Soc. 80, 6223–6230Google Scholar

Copyright information

© Springer-Verlag 1976

Authors and Affiliations

  • Daniel G. Odom
    • 1
  • John T. Brady
    • 1
  • John Oro
    • 2
  1. 1.Department of Surgery, Letterman Army Institute of ResearchPresidio of San FranciscoUSA
  2. 2.Department of Biophysical Sciences University of HoustonHoustonUSA

Personalised recommendations