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Prebiotic peptide-formation in the solid state

III. Condensation Reactions of Glycine in Solid State Mixtures Containing Inorganic Polyphosphates

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Summary

The reactions of glycine with inorganic polyphosphates in the solid state have been studied. The formation of peptides up to the decamer occurs at moderate temperatures (r.t.−100°C) in the presence of imidazole and magnesium chloride. If adenosine 5′-monophosphate is added to the reaction mixture, 2′(3′)-O-glycyl adenosine 5′-monophosphate is also obtained. These reactions could have occurred on the primitive earth.

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Sawai, H., Orgel, L.E. Prebiotic peptide-formation in the solid state. J Mol Evol 6, 185–197 (1975). https://doi.org/10.1007/BF01732355

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  • DOI: https://doi.org/10.1007/BF01732355

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