Advertisement

Klinische Wochenschrift

, Volume 63, Issue 4, pp 190–191 | Cite as

Local hirudin application — an aid in preventing occlusion of an arteriovenous fistula in dialysis patients?

  • E. Minar
  • J. Zazgornik
Wissenschaftliche Kurzmitteilungen

Summary

In this pilot study we tested the effect of an ointment containing hirudin in a high concentration [20,000 ATU (antithrombin units)/100 g ointment] in ten patients on maintenance haemodialysis (six men, four women; mean age: 51 years; mean duration of dialysis treatment: 20.4 months). The duration of hirudin application was 4.5 months, the observation period in the total group was 43 months. During the total dialysis period of 204 months — before hirudin application — in these ten patients a shunt thrombectomy was necessary 18 times because of shunt occlusion. A shunt-thrombosis occurred in none of the ten patients during the period of application of the hirudincontaining ointment.

Key words

Hirudin Arteriovenous fistula Haemodialysis 

Abkürzungen

ATU

antithrombin units

References

  1. 1.
    Bartek MJ, La Budde AJ, Maibach HI (1972) Skin permeability in vivo: comparison in rat, rabbit, pig and man. J Invest Dermatol 58:114–123Google Scholar
  2. 2.
    Markwardt F (1955) Untersuchungen über Hirudin. Naturwissenschaften 42:537–538Google Scholar
  3. 3.
    Markwardt F, Hauptmann J, Nowak G, Kleßen Ch, Walsmann P (1982) Pharmacological studies on the antithrombotic action of hirudin in experimental animals. Thromb Haemostas 47:226–229Google Scholar
  4. 4.
    Petersen TE, Roberts HR, Sottrup-Jensen L, Magnusson S (1976) Primary structure of hirudin, a thrombin-specific inhibitor. In: Peeters H (ed) Protides of the Biological Fluids. Vol. 23. Pergamon Press, Oxford, pp 145–149Google Scholar
  5. 5.
    Stölzle A (1982) Zur percutanen Resorption der Proteinaseinhibitoren Hirudin, Eglin und Bdellin aus dem Blutegel Hirudo medicinalis. In vivo — und in vitro — Studien am Meerschweinchen. Inaugural — Dissertation, MünchenGoogle Scholar
  6. 6.
    Walsmann P, Markwardt F (1981) Biochemische und pharmakologische Aspekte des Thrombininhibitors Hirudin. Pharmazie 36:653–660Google Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • E. Minar
    • 1
  • J. Zazgornik
    • 1
  1. 1.I. Medizinische Universitätsklinik WienAustria

Personalised recommendations