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Protein-liposome interactions and their relevance to the structure and function of cell membranes

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Summary

Recent studies on the interactions of soluble proteins, membrane proteins and enzymes with phospholipid model membranes are reviewed. Similarities between the properties of such systems and the behavior of biomembranes, such as alterations in the redox potential of cytochromec after binding to membranes and effects of phospholipid fluidity on (Na + K) ATPase activity, are emphasized. The degree of correspondence between the behavior of model systems and natural membranes encourages the continuing use of model membranes in studies on protein-lipid interactions. However, some of the data on the increase of surface pressure of phospholipid monolayers by proteins and increases in the permeability of liposomes indicate that many soluble proteins also have a capability to interact hydrophobically with phospholipids. Thus a sharp distinction between both peripheral and integral membrane proteins and non-membrane proteins are not seen by these techniques. Cautious use of such studies, however, should lead to greater understanding of the molecular basis of cell membrane structure and function in normal and pathological states. Studies implicating protein-lipid interactions and (Na + K) ATPase activity in membrane alterations in disease states are also briefly discussed.

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References

  1. Davson, H. and Danielli, J. F., The Permeability of Natural Membranes, 1952 edition, reprinted 1970 by Hofner Publishing Company, Darien, Conn.

  2. Claude, A., J. Exp. Med. 84, 51–89 (1946).

    Google Scholar 

  3. Keilin, D., Proc. Roy. Soc. B. 106, 418–444 (1930).

    Google Scholar 

  4. Keilin, D. and Hartree, E. F., Proc. Roy. Soc. B. 122, 298–308 (1937).

    Google Scholar 

  5. Singer, S. J. and Nicolson, G. L., Science 175, 720–731 (1972).

    Google Scholar 

  6. Smith, L. and Stotz, E., J. Biol. Chem. 209, 819–828 (1954).

    Google Scholar 

  7. Vanderkooi, S. G., Biochim. Biophys. Acta 344, 307–345 (1974).

    Google Scholar 

  8. Jurtshuk, P. Jr., Sekuzu, I. and Green, D. E., Biochem. and Biophys. Res. Commun. 6, 76–80 (1961).

    Google Scholar 

  9. Coleman, R., Biochim. Biophys. Acta 300, 1–30 (1973).

    Google Scholar 

  10. Skou, J. C., Physiol. Rev. 45, 596–617 (1965).

    Google Scholar 

  11. Winzler, R. J., in: Red Cell Membrane Structure and Function, p. 157 (Jamieson, F. A. and Greenawalt, T. J., editors). J. B. Lippincott, Philadelphia, Penn. (1969).

    Google Scholar 

  12. Dahl, J. L. and Hokin, L. E., Ann. Rev. of Biochem. 43, 327–356 (1974).

    Google Scholar 

  13. Marchesi, V. T., Jackson, R. L., Segrest, J. P. and Kahane, I., Fed. Proc. 32, 1833–1837 (1973).

    Google Scholar 

  14. Kaplan, D. M. and Criddle, R. S., Physiol. Rev. 51, 249–272 (1971).

    Google Scholar 

  15. Singer, S. J., Ann. Rev. Biochem. 43, 805–833 (1974).

    Google Scholar 

  16. Makino, S., Reynolds, J. A. and Tanford, C., J. Biol. Chem. 248, 4926–4932 (1973).

    Google Scholar 

  17. Rouser, G., Nelson, G. J., Fleischer, S. and Simon, G., in: Biological Membrane Physical Fact and Function, pp. 5–69, (Chapman, D., editor) Academic Press, New York and London (1968).

    Google Scholar 

  18. Bangham, A. D., Standish, M. M. and Watkins, J. C., J. Mol. Biol. 13, 238–252 (1965).

    Google Scholar 

  19. Small, D. M., J. Lipid Res. 8, 551–557 (1967).

    Google Scholar 

  20. Papahadjopoulos, D. and Miller, N., Biochim. Biophys. Acta 135, 624–638 (1967).

    Google Scholar 

  21. Bangham, A. D., Hill, M. W. and Miller, N. G. A., in: Methods in Membrane Biology, 1, pp. 1–68, (Korn, E. D., editor) Plenum Press, New York and London (1974).

    Google Scholar 

  22. Mueller, P., Rudin, D. O., Tien, H. T. and Westcott, W. C., Nature 194, 979–980 (1962).

    Google Scholar 

  23. Steinemann, A. and Läuger, P., J. Membrane Biol. 4, 74–81 (1971).

    Google Scholar 

  24. Montal, M., J. Membrane Biol. 7, 245–266 (1972).

    Google Scholar 

  25. Steim, J. M., Tourtellotte, M. E., Reinert, J. C., McElhaney, R. N. and Rader, J. C., Proc. Nat. Acad. Sci. (U.S.A.) 63, 104–109 (1969).

    Google Scholar 

  26. Blazyk, J. F. and Steim, J. M., Biochim. Biophys. Acta 266, 737–741 (1972).

    Google Scholar 

  27. Shipley, G. G., in: Biological Membranes, (Chapman, D. and Wallach, D. F. H., editors) 2, pp. 1–89, Academic Press, London and New York (1973).

    Google Scholar 

  28. Chapman, D., in: Biological Membranes, (Chapman, D. and Wallach, D. F. H., editors) 2, pp. 91–144, Academic Press, London and New York (1973).

    Google Scholar 

  29. Bretscher, M. S., Science 181, 622–629 (1973).

    Google Scholar 

  30. Gitler, C., Ann. Rev. Biophys. and Bioengineering 1, 51–92 (1972).

    Google Scholar 

  31. Sweet, C. and Zull, J. E., Biochim. Biophys. Acta 173, 94–103 (1969).

    Google Scholar 

  32. Kimelberg, H. K. and Papahadjopoulos, D., J. Biol. Chem. 246, 1142–1148 (1971).

    Google Scholar 

  33. Papahadjopoulos, D., Biochim. Biophys. Acta 241, 254–259 (1971).

    Google Scholar 

  34. Calissano, P., Alema, S. and Rusca, G., Biochim. Biophys. Acta 255, 1009–1013 (1972).

    Google Scholar 

  35. Kaplan, J. H., Biochim. Biophys. Acta 311, 1–5 (1973).

    Google Scholar 

  36. Kimelberg, H. K., Lee, C. P., Claude, A. and Mrena, E., J. Membrane Biol. 2, 235–251 (1970).

    Google Scholar 

  37. Kimelberg, H. K. and Papahadjopoulos, D., Biochim. Biophys. Acta 233, 805–809 (1971).

    Google Scholar 

  38. Gulik-Krzywicki, T., Schechter, E., Luzzati, V. and Faure, M., Nature 223, 1116–1121 (1969).

    Google Scholar 

  39. Kamat, V. B., Chapman, D., Zwaal, R. F. A. and Van Deenen, L. L. M., Chem. Phys. Lipids 4, 323–331 (1970).

    Google Scholar 

  40. Mukai, K., Land, C. M. and Chesnut, D. B., Chem. Phys. Lipids 9, 196–216 (1972).

    Google Scholar 

  41. Vanderkooi, J., Erecinska, M. and Chance, B., Arch. Biochem. and Biophys. 154, 219–229 (1973).

    Google Scholar 

  42. Papahadjopoulos, D., Jacobson, K., Nir, S. and Isac, T., Biochim. Biophys. Acta 311, 330–348 (1973).

    Google Scholar 

  43. De Gier, J., Mandersloot, J. G. and Van Deenen, L. L. M., Biochim. Biophys. Acta 150, 666–675 (1969).

    Google Scholar 

  44. Papahadjopoulos, D., Cowden, M. and Kimelberg, H. K., Biochim. Biophys. Acta 330, 8–26 (1973).

    Google Scholar 

  45. Tenenbaum, D. and Folch-Pi, J., Biochim. Biophys. Acta 115, 141–147 (1966).

    Google Scholar 

  46. Juliano, R. L., Kimelberg, H. K. and Papahadjopoulos, D., Biochim. Biophys. Acta 241, 894–905 (1971).

    Google Scholar 

  47. Dawson, R. M. C. and Quinn, P. J., in: Membrane-Bound Enzymes, (Porcellati, G. and di Jeso, F., editors) p. 1, Plenum Press, New York and London (1971).

    Google Scholar 

  48. Nicholls, P., Biochim. Biophys. Acta 346, 261–310 (1974).

    Google Scholar 

  49. Kimelberg, H. K., Ph.D. Dissertation, State University of New York at Buffalo, University Microfilms Ltd. Ann Arbor, Michigan (1968).

  50. Kimelberg, H. K. and Lee, C. P., Biochim. Biophys. Res. Comm., 34, 784–790 (1969).

    Google Scholar 

  51. Dickerson, R. E., Takano, T., Eisenberg, D., Kallai, O. B., Samson, L., Cooper, A. and Margoliash, E., J. Biol. Chem. 246, 1511–1535 (1971).

    Google Scholar 

  52. Colacicco, G., Lipids 5, 636–649 (1970).

    Google Scholar 

  53. Bigelow, C. C., J. Theoret. Biol. 16, 187–211 (1967).

    Google Scholar 

  54. Helenius, A. and Simons, K., J. Biol. Chem. 247, 3656–3661 (1972).

    Google Scholar 

  55. Neer, E. J., J. Biol. Chem. 249, 6527–6531 (1974).

    Google Scholar 

  56. Hammes, G. G. and Schullery, S. E., Biochemistry 9, 2555–2563 (1970).

    Google Scholar 

  57. Letellier, L. and Schechter, E., Eur. J. Biochem. 40, 507–512 (1973).

    Google Scholar 

  58. Kimelberg, H. K. and Lee, C. P., J. Membrane Biol. 2, 252–262 (1970).

    Google Scholar 

  59. Dutton, P. L., Wilson, D. F. and Lee, C. P., Biochemistry 9, 5077–5082 (1970).

    Google Scholar 

  60. Dutton, P. L. and Wilson, D. F., Biochim. Biophys. Acta 346, 165–212 (1974).

    Google Scholar 

  61. Nicolson, G. L. and Painter, R. G., J. Cell Biol. 59, 395–406 (1973).

    Google Scholar 

  62. O'Brien, J. S. and Sampson, E. L., J. Lipid Res. 6, 537–544 (1965).

    Google Scholar 

  63. London, Y., Demel, R. A., Van Kessel Geurts, W. S. M., Zahler, P. and Van Deenen, L. L. M., Biochim. Biophys. Acta 332, 69–84 (1974).

    Google Scholar 

  64. Demel, R. A., London, Y., Van Kessel Geurts, W. S. M., Vossenberg, F. G. A. and Van Deenen, L. L. M., Biochim. Biophys. Acta 311, 507–519 (1973).

    Google Scholar 

  65. London, Y., Demel, R. A., Van Kessel Guerts, W. S. M., Vossenberg, F. G. A. and Van Deenen, L. L. M., Biochim. Biophys. Acta 311, 520–530 (1973).

    Google Scholar 

  66. Wood, J. G., Dawson, R. M. C. and Hauser, H., J. of Neurochem. 22, 637–643 (1974).

    Google Scholar 

  67. Zwaal, R. F. A. and Van Deenen, L. L. M., Chem. Phys. Lipids 4, 311–322 (1970).

    Google Scholar 

  68. Tosteson, M. T., Lav, F. and Tosteson, D. C., Nature New Biology 243, 112 (1973).

    Google Scholar 

  69. Capaldi, R. A. and Vanderkooi, G., Proc. Nat. Acad. Sci. 69, 930–932 (1972).

    Google Scholar 

  70. Tanford, C., J. Mol. Biol. 67, 59–74 (1972).

    Google Scholar 

  71. Triggle, D. J., in: Recent Progress in Surface Science, (Danielli, J. F., Riddiford, A. C. and Rosenberg, M. D., editors) 3, pp. 273–290, Academic Press, New York (1970).

    Google Scholar 

  72. Kagawa, Y., Biochim. Biophys. Acta 265, 297–338 (1972).

    Google Scholar 

  73. Razin, S., Biochim. Biophys. Acta 265, 241–296 (1972).

    Google Scholar 

  74. Papahadjopoulos, D. and Kimelberg, H. K., in: Progress in Surface Science, (Davison, S. G., editor) 4, pp. 141–232, Pergamon Press, Oxford (1973).

    Google Scholar 

  75. Fourcans, B. and Jain, M. K., in: Advances in Lipid Research, (Paoletti, R. and Kritchevsky, D., editors) 12, pp. 147–226, Academic Press, New York and London (1974).

    Google Scholar 

  76. Katz, B., Muscle and Synapse, McGraw-Hill Inc., New York (1966).

    Google Scholar 

  77. Thomas, R. C., Physiological Reviews 52, 563–594 (1972).

    Google Scholar 

  78. Tosteson, D. C., in: The Cellular Functions of Membrane Transport, (Hoffman, J. E., editor) pp. 3–22, Prentice-Hall Inc., Englewood Cliffs (1963).

    Google Scholar 

  79. Quastel, M. R. and Kaplan, J. G., Exper. Cell Res. 63, 230–233 (1970).

    Google Scholar 

  80. Ohnishi, T. and Kawamura, H., J. of Biochem. 56, 377–378 (1964).

    Google Scholar 

  81. Kimelberg, H. K. and Papahadjopoulos, D., J. Biol. Chem. 249, 1071–1080 (1974).

    Google Scholar 

  82. Tanaka, R. and Strickland, K. P., Arch. Biochem. Biophys. 111, 583–592 (1965).

    Google Scholar 

  83. Fenster, L. J. and Copenhaver, J. H., Biochim. Biophys. Acta 137, 406–408 (1967).

    Google Scholar 

  84. Emmelot, P. and Bos, C. J., Biochim. Biophys. Acta 150, 341–353 (1968).

    Google Scholar 

  85. Noguchi, T. and Freed, S., Nature New Biol. 230, 148–150 (1971).

    Google Scholar 

  86. Jarnefelt, J., Biochim. Biophys. Acta 266, 91–96 (1972).

    Google Scholar 

  87. Roelofsen, B. and Van Deenen, L. L. M., Europ. J. of Biochem. 40, 245–257 (1973).

    Google Scholar 

  88. Goldman, S. S. and Albers, R. W., J. Biol. Chem. 243, 867–874 (1973).

    Google Scholar 

  89. De Pont, J. J. H. H. M., Van Prooijen-Van Eeden, A. and Bonting, S. L., Biochim. Biophys. Acta 323, 487–494 (1973).

    Google Scholar 

  90. Cook, A. M., Low, E. and Ishizimi, M., Nature New Biol. 239, 150–151 (1972).

    Google Scholar 

  91. Tanaka, R. and Sakamoto, T., Biochim. Biophys. Acta 193, 384–393 (1969).

    Google Scholar 

  92. Tanaka, R., Sakamoto, T. and Sakamoto, Y., J. Membrane Biol. 4, 42–51 (1971).

    Google Scholar 

  93. Sun, A. Y., Sun, G. Y. and Samorajski, T., J. of Neurochem. 18, 1711–1718 (1971).

    Google Scholar 

  94. Taniguchi, K. and Tonomura, Y., J. Biochem. 69, 543–557 (1971).

    Google Scholar 

  95. Kimelberg, H. K. and Papahadjopoulos, D., Biochim. Biophys. Acta 282, 277–292 (1972).

    Google Scholar 

  96. Hokin, L. E. and Hexum, T. D., Arch. Biochem. Biophys. 151, 453–463 (1972).

    Google Scholar 

  97. Wheeler, K. P. and Whittam, R., J. Physiol. 207, 303–328 (1970).

    Google Scholar 

  98. Raison, J. K., Bioenergetics 4, 285–309 (1973).

    Google Scholar 

  99. Overath, P., Schairer, H. U. and Stoffel, W., Proc. Nat. Acad. Sci. (U.S.A.) 67, 606–612 (1970).

    Google Scholar 

  100. Wilson, G., Rose, S. P. and Fox, C. F., Biochem. Biophys. Res. Commun. 38, 617–623 (1970).

    Google Scholar 

  101. Esfahani, M., Limbrick, A. R., Knutton, S., Oka, T. and Wakil, S. J., Proc. Nat. Acad. Sci. 68, 3180–3184 (1971).

    Google Scholar 

  102. Mavis, R. D. and Vagelos, P. R., J. Biol. Chem. 247, 652–659 (1972).

    Google Scholar 

  103. Ladbrooke, B. D., Williams, R. M. and Chapman, D., Biochim. Biophys. Acta 150, 333–340 (1968).

    Google Scholar 

  104. Trauble, H. and Eibl, H., Proc. Nat. Acad. Sci. 71, 214–219 (1974).

    Google Scholar 

  105. Hazel, J. R. and Prosser, C. L., Physiol. Reviews 54, 620–677 (1974).

    Google Scholar 

  106. Grisham, C. M. and Barnett, R. E., Biochem. 12, 2635–2637 (1973).

    Google Scholar 

  107. Linden, C. D., Wright, K. L., McConnell, H. M. and Fox, C. F., Proc. Nat. Acad. Sci. (U.S.A.) 70, 2271–2275 (1973).

    Google Scholar 

  108. Devaux, P. and McConnell, H. M., J. Amer. Chem. Soc. 94, 4475–4481 (1972).

    Google Scholar 

  109. Frye, L. D. and Edidin, M., J. Cell. Sci. 7, 319–335 (1970).

    Google Scholar 

  110. Kleeman, W. and McConnell, H. M., Biochim. Biophys. Acta 345, 220–230 (1974).

    Google Scholar 

  111. De Kruyff, B., Van Dijck, P. W. M., Goldbach, R. W., Denez, R. A. and Van Deenen, L. L. M., Biochim. Biophys. Acta 330, 269–282 (1973).

    Google Scholar 

  112. Chapman, D., Owens, N. F., Phillips, M. C. and Walker, D. A., Biochim. Biophys. Acta 183, 458–465 (1969).

    Google Scholar 

  113. Green, D. E. and Fleischer, S., Biochim. Biophys. Acta 70, 554–582 (1963).

    Google Scholar 

  114. Papahadjopoulos, D., Nir, S. and Ohki, S., Biochim. Biophys. Acta 266, 561–583 (1971).

    Google Scholar 

  115. Slack, J. R., Anderson, B. H. and Day, W. A., Biochim. Biophys. Acta 323, 547–559 (1973).

    Google Scholar 

  116. Hinkle, P. C., Kim, J. J. and Racker, E., J. Biol. Chem. 247, 1338–1339 (1972).

    Google Scholar 

  117. Goldin, S. M. and Tong, S. W., J. Biol. Chem. 249, 5907–5915 (1974).

    Google Scholar 

  118. Hilden, S., Rhee, H. M. and Hokin, L. E., J. Biol. Chem. 249, 7432–7440 (1974).

    Google Scholar 

  119. Warren, G. B., Toon, P. A., Birdsall, N. J. M., Lee, A. G. and Metcalfe, J. C., Proc. Nat. Acad. Sci. (U.S.A.) 71, 622–626 (1974).

    Google Scholar 

  120. Inesi, G., Millman, M. and Eletr, S., J. Mol. Biol. 81, 483–504 (1973).

    Google Scholar 

  121. Gruener, N. and Avi-Dor, Y., J. Biochem. 100, 762–767 (1966).

    Google Scholar 

  122. Swanson, P. D., J. Neurochem. 13, 229–236 (1966).

    Google Scholar 

  123. Charnock, J. S., Doty, D. M. and Russell, J. C., Arch. Biochem. Biophys. 142, 633–637 (1971).

    Google Scholar 

  124. Bowler, K. and Duncan, C. J., Comp. Biochem. Physiol. 24, 1043–1054 (1968).

    Google Scholar 

  125. Taniguchi, K. and Iida, S., Biochim. Biophys. Acta 274, 536–541 (1972).

    Google Scholar 

  126. Smith, M. W., Biochem. J. 105, 65–71 (1967).

    Google Scholar 

  127. Kimzey, S. L. and Willis, J. S., J. of General Physiology 58, 634–649 (1971).

    Google Scholar 

  128. Kemp, A., Groot, G. S. P. and Reitsna, H. J., Biochim. Biophys. Acta 180, 28–34 (1969).

    Google Scholar 

  129. Lyons, J. M. and Raison, J. K., Comp. Biochem. Physiol. 37, 405–411 (1970).

    Google Scholar 

  130. Lenaz, G., Sechi, A. M., Parenti-Castelli, G., Landi, L. and Bertoli, E., Biochem. Biophys. Res. Commun. 49, 536–542 (1972).

    Google Scholar 

  131. Watson, K., Bertoli, E. and Griffiths, D. E., FEBS Letters 30, 120–124 (1973).

    Google Scholar 

  132. Lee, M. P. and Gear, A. R. L., J. Biol. Chem. 249, 7541–7549 (1974).

    Google Scholar 

  133. Eletr, S., Zakin, D. and Vessey, D. A., J. Molec. Biol. 78, 351–362 (1973).

    Google Scholar 

  134. Kreiner, P. W., Keirns, J. J. and Bitensky, M. W., Proc. Nat. Acad. Sci. (U.S.A.) 70, 1785–1789 (1973).

    Google Scholar 

  135. Bar, H. P., Molec. Pharmacol. 10, 597–604 (1974).

    Google Scholar 

  136. Chapman, D. and Urbina, FEBS Letters 12, 169 (1971).

    Google Scholar 

  137. Papahadjopoulos, D. and Isac, T., Fed. Proc. 33, 1254 (1974).

    Google Scholar 

  138. Jost, P., Griffith, O. H., Capaldi, R. A. and Vanderkooi, G., Biochim. Biophys. Acta 311, 141–152 (1973).

    Google Scholar 

  139. Bergelson, L. D., Dyatlovitskaya, E. V., Torkovskaya, T. I., Sorokina, I. B. and Gorkova, N. P., Biochim. Biophys. Acta 210, 287–298 (1970).

    Google Scholar 

  140. Karlsson, K. A., Samuelsson, B. E., Schersten, T., Steen, G. O. and Wahlquist, L., Biochim. Biophys. Acta 337, 349–355 (1974).

    Google Scholar 

  141. Feo, F., Canuto, R. A., Bertone, G., Garcea, R. and Pani, P., FEBS Letters 33, 229–232 (1973).

    Google Scholar 

  142. Wallach, D. F. H., in: Biological Membranes, (Chapman, D. and Wallach, D. F. H., editors) 2, pp. 253–294, Academic Press, New York and London (1973).

    Google Scholar 

  143. Yanagihara, T. and Cummings, J. N., Brain 92, 59–70 (1969).

    Google Scholar 

  144. Suzuki, O. and Yagi, K., Experientia 30, 248 (1974).

    Google Scholar 

  145. Perdue, J. F., Kletzien, R., Miller, K., Pridmore, G. and Wray, V. L., Biochim. Biophys. Acta 249, 435–453 (1971).

    Google Scholar 

  146. Yau, T. M. and Weber, M. J., Biochem. Biophys. Res. Commun. 49, 114–120 (1972).

    Google Scholar 

  147. Sheinin, R. and Onoderce, K., Biochim. Biophys. Acta 274, 49–63 (1972).

    Google Scholar 

  148. Graham, J. M., Biochem. J. 130, 1113–1124 (1972).

    Google Scholar 

  149. Yoshikawada-Fukada, M. and Nojima, T., J. Cell. Physiol. 80, 421–430 (1972).

    Google Scholar 

  150. Patterson, M. K. Jr., J. of Nat. Cancer Inst. 53, 1493–1498 (1974).

    Google Scholar 

  151. Kasarov, L. B. and Briedman, H., Cancer Res. 34, 1862–1865 (1974).

    Google Scholar 

  152. Kimelberg, H. K. and Mayhew, E., J. Biol. Chem. 250, 100–104 (1975).

    Google Scholar 

  153. Verdouw, H. and Bertina, R. M., Biochim. Biophys. Acta 325, 385–396 (1973).

    Google Scholar 

  154. Weber, M. J., J. Biol. Chem. 248, 2978–2983 (1973).

    Google Scholar 

  155. Isselbacher, K. J., Proc. Nat. Acad. Sci. (U.S.A.) 69, 585–589 (1972).

    Google Scholar 

  156. Kimelberg, H. K., Fed. Proc. 34, 642 (1975).

    Google Scholar 

  157. Janicki, R. H. and Kinter, W. B., Nature New Biol. 233, 148–149 (1971).

    Google Scholar 

  158. Secchi, G., Alessio, L. and Cambiaghi, G., Arch. Environ. Health 27, 399–400 (1973).

    Google Scholar 

  159. Stastny, F., Antosova, E., Kostir, J. and Jilek, L., Brain Res. 33, 597–600 (1972).

    Google Scholar 

  160. Lim, R., De la Torre, J. C. and Mullan, S., Arch. Neurol. 27, 314–321 (1972).

    Google Scholar 

  161. Laws, E. R. and O'Connor, J. S., J. Neurosurg. 33, 167–171 (1970).

    Google Scholar 

  162. Bray, G. M., Biochim. Biophys. Acta 298, 239–245 (1973).

    Google Scholar 

  163. Palatini, P., Dabbeni-Sala, F. and Bruni, A., Biochim. Biophys. Acta 288, 413–422 (1972).

    Google Scholar 

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  1. Division of Neurosurgery and Department of Biochemistry, The Albany Medical College of Union University, 12208, Albany, New York, USA

    Harold K. Kimelberg

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Kimelberg, H.K. Protein-liposome interactions and their relevance to the structure and function of cell membranes. Mol Cell Biochem 10, 171–190 (1976). https://doi.org/10.1007/BF01731688

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