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Intensive Care Medicine

, Volume 17, Supplement 1, pp S20–S23 | Cite as

Sedation in the ICU

  • H. R. Vinik
  • I. Kissin
Article

Abstract

The effect of midazolam on the induction dose-response curve for alfentanil was studied in non-premedicated ASA physical status I or II patients. The response to the verbal command was used as an end point of anaesthesia. Dose-response curves for midazolam, alfentanil, and their combination were determined with a probit procedure, and compared with algebraic (fractional) analysis of drug interaction. Interaction between midazolam and alfentanil was found to be synergistic (supra-additive). The results suggest that the use of this combination is advantageous not only because it helps to achieve different anaesthetic goals with specific drugs (a benzodiazepine for unconsciousness and an opioid for blockade of the responses to noxious stimulation), but also because its components are complementary for unconsciousness.

Key words

Intravenous anaesthetics Analgesics Hypnotics Benzodiazepines Drug interactions Midazolam Alfentanil 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • H. R. Vinik
    • 1
  • I. Kissin
    • 1
  1. 1.Department of AnesthesiologyThe University of Alabama at BirminghamBirminghamUSA

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