Abstract
Five alleles with eight electrophoretic phenotypes of 6-phosphogluconate dehydrogenase were found in 1,195 blood samples from fourteen populations of nine macaque species.Macaca fascicularis from Malaya showed the most polymorphism, with three Pgd alleles resulting in five phenotypes.Macaca mulatta, M. speciosa, M. nemestrina, andM. cyclopis had two alleles each (although the last two species showed a high percentage of homozygosity). The remaining four species (M. fuscata, M. radiata, M. maura, andM. nigra) were homozygous for the Pgda allele. The predominance of Pgda was observed in all macaque species, exceptM. speciosa which showed a high (57%) frequency of Pgdd. The distinctive position ofM. speciosa with regard to 6PGD variants parallels observations that indicate that this species carries transferrin and carbonic anhydrase I alleles in different frequencies from those of the other macaque species. Other similarities between the patterns of transferrin and 6PGD variations include a tendency toward homozygosity at the Pgd locus in the insular macaque forms. However, in this case only the Pgda allele is involved, while some variation was found in the transferrin alleles fixed by the founder effect in the insular macaques.
This is a preview of subscription content, log in via an institution to check access.
References
Davidson, R. G., 1967. Electrophoretic variants of human 6-phosphogluconate dehydrogenase: population and family studies and description of a new variant.Ann. Hum. Genet. 30: 355–361.
Goodman, M., 1968. Evolution of the catarrhine primates at the macromolecular level. In:Primates in Medicine, 1: First Holloman Symposium on Primate Immunology and Molecular Genetics C. H. Kratochvil (ed.), Karger, Basel & New York, pp. 10–26.
——, 1965. Species and geographic differences in the transferrin polymorphism of macaques.Science, 147: 884–886.
Kazazian, H. H., Jr., W. J. Young, &B. Childs, 1965. X-linked 6-phosphogluconate dehydrogenase inDrosophila: subunit associations.Science 150: 1601–1602.
Mayr, E., 1965.Animal Species and Evolution Belknap Press, Harvard, pp.XIV + 797.
Parr, C. W., 1966. Erythrocyte phosphogluconate dehydrogenase polymorphism.Nature, London, 210: 487–489.
——, 1967. Inherited quantitative variations of human phosphogluconate dehydrogenase.Ann. Hum. Genet. 30: 339–353.
Prychodko, W., M. Goodman, E. Poulik, T. Miki, &T. Tanaka, 1969. Geographic variations of transferrin allelic frequencies in continental and insular macaque populations.Proc. 2nd. Int. Congr. Primat., Atlanta, Ga., 1968 H. O. Hofer (ed.), Karger, Basel & New York, 2: 103–108.
Shaw, C. R., 1965. Electrophoretic variation in enzymes.Science 149: 936–943.
Shows, T. B., R. E. Tashian, &G. Brewer, 1964. Erythrocyte glucose-6-phosphate dehydrogenase in Caucasians: new inherited variant.Science 145: 1056–1057.
Smithies, O., 1955. Zone electrophoresis in starch gels: group variations in serum proteins of normal human adults.Biochem. J. 61: 629–641.
Tashian, R. E., M. Goodman, V. E. Headings, J. DeSimone, & R. H. Ward. Genetic variation and evolution in the red cell carbonic anhydrase isozymes of macaque monkeys. (Manuscript)
Thuline, H. C., A. C. Morrow, D. E. Norby, &H. G. Motulsky, 1967. Autosomal phosphogluconic dehydrogenase polymorphism in the cat (Felis catus L.).Science 157: 431–432.
Author information
Authors and Affiliations
Additional information
This research was supported by NSF grants GF 253, GB 7426, and GB 15060 of the U.S.-Japan Cooperative Science and Systematic Biology Programs.
About this article
Cite this article
Prychodko, W., Goodman, M., Singal, B.M. et al. Starch-gel electrophoretic variants of erythrocyte 6-phosphogluconate dehydrogenase in asian macaques. Primates 12, 175–182 (1971). https://doi.org/10.1007/BF01730393
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01730393