Abstract
A local epizootic of tuberculosis in a laboratory colony of baboons was controlled by 40–80 mg/kg daily dose of Isoniazid. There was definite regression of disease in all animals examined at autopsy, after three weeks and three months of therapy, following their use for unrelated acute experiments. One animal survives in apparent health with a healthy infant that was born after 102 days of therapy.
References
Allen, A. M. &R. G. Kinard, 1958. Primary cutaneous inoculation tuberculosis in theMacaca mulatta monkey.Amer. J. Path. 34: 337–345.
Calmette, A., 1923.Tubercle Bacillus Infection and Tuberculosis in Man and Animals. Williams & Wilkins Company, Baltimore.
Chrisp, C. E., B. J. Cohen, D.H. Ringler, &G. D. Abrams, 1968. Tuberculosis in a squirrel monkey (Saimiri sciureus).J. amer. vet. med. Assoc. 153: 918–922.
Clarke, G. L. &J. P. Schmidt, 1969. Effect of prophylactic isoniazid on early developing experimental tuberculosis inMacaca mulatta.Am. Rev. resp. Dis. 100: 224–227.
Fremming, B. D., R. E. Benson, R. J. Young, &M. D. Harris, Jr., 1957. Antituberculosis therapy inMacaca mulatta monkeys.Amer. Rev. Tuberc. 76: 225–231.
Habel, K., 1947. Tuberculosis in a laboratory monkey colony: Its spread and control.Amer. Rev. Tuberc. 55: 77–92.
Hessler, J. R. &A. F. Moreland, 1968. Pulmonary tuberculosis in a squirrel monkey (Saimiri sciureus).J. amer. vet. med. Assoc. 153: 923–927.
Hill, W. C. O., 1969. The use of primates in biomedical studies: A review of suitable species.Ann. N. Y. Acad. Sci. 162: 7–14.
Keeling, N. E., R. E. Froehlich, &R. D. Ediger, 1969. An epizootic of tuberculosis in a rhesus monkey conditioning colony.Laboratory Animal Care 19: 629–634.
Kim, C. S., A. K. Eugster, &S. S. Kalter, 1968. Pathologic study of the African baboon (Papio sp.) in his native habitat.Primates 9: 93–104.
Neset, G., 1964. Specific drug therapy in pulmonary tuberculosis.Acta chir. scand. Suppl. 335: 1–94.
Ruch, T. C., 1959.Dieseases of Laboratory Primates. W. B. Saunders Company, Philadelphia. pp. 199–253.
Schmidt, L. H., R. Hoffmann, &H. B. Hughes, 1953. The toxicity of isoniazid for the rhesus monkey.Amer. Rev. Tuberc. 67: 798–807.
——, &N. Jolly, 1955. Induced pulmonary tuberculosis in the rhesus monkey: Its usefulness in evaluating chemotherapeutic agents.Trans. Conf. on the Chemotherapy of Tuberc. 14: 226–231.
Sibinoric, S., 1969. Tuberculin testing in monkeys (Macaca mulatta) with naturally occurring tuberculosis.Laboratory Animal Care 19: 621–623.
Urbain, A., 1938. L'Infection tuberculeuse spontanée chez les mammifères sauvages en captivité.Annales de l'Institut Pasteur 61: 705–730.
Vice, T. E., M. E. Pinkerton, F.A. Fear, &S. S. Kalter, 1968. An outbreak of tuberculosis in a group of experimental baboons.Primates 9: 105–122.
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Allgood, M.A., Price, G.T. Isoniazid therapy of tuberculosis in baboons. Primates 12, 81–90 (1971). https://doi.org/10.1007/BF01730384
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DOI: https://doi.org/10.1007/BF01730384