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Evaluation of indeterminate sera for hepatitis C virus by assays using synthetic peptides

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Abstract

The development of new immunodiagnostic systems to study antibodies anti-HCV based on the use of synthetic peptides are potentially very important in the evaluation of indeterminate samples. We have compared two immunodiagnostic tests, the 3-RIBA and LIA-HCV test system, to examine the samples rated as indeterminate by the 2-RIBA test. The results showed that the specificity of the new tests has improved, in fact 29/40 of the indeterminate samples studied became positive with both tests. However, the 3-RIBA test showed higher sensitivity, since two samples negative by LIA-HCV, were positive with this system.

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Rivanera, D., Lorino, G., Lilli, D. et al. Evaluation of indeterminate sera for hepatitis C virus by assays using synthetic peptides. Eur J Epidemiol 10, 235–237 (1994). https://doi.org/10.1007/BF01730378

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  • DOI: https://doi.org/10.1007/BF01730378

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