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Interleukin-6 in clinical medicine

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Summary

This article covers the basic biological functions of interleukin-6 (IL-6) in man. Three major topics are addressed more closely: the involvement of IL-6 in various disease states, particularly those of hematopoietic origin; the diagnostic usefulness of IL-6 measurements in biological fluids; the possible use of IL-6, IL-6 antagonists or IL-6 derivatives as therapeutic means.

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References

  1. Aarden LA, De Groot ER, Schaap OL, Lansdorp PM (1987) Production of hybridoma growth factor by human monocytes. Eur J Immunol 17: 1411–1416

    Google Scholar 

  2. Akira S, Hirano T, Taga T, Kishimoto T (1990) Biology of multifunctional cytokines: IL-6 and related molecules. FASEB J 4: 2860–2867

    Google Scholar 

  3. Andus T, Gross V, Cäsar J, Krumm D, Hosp J, David M, Schölmerich J (1991) Activation of monocytes during inflammatory bowel disease. Pathobiol (in press)

  4. Asano S, Okano A, Ozawa K, Nakahata T, Ishibashi T, Koike K, Kimura H, Tanioka Y, Shibuya A, Hirano T, Kishimoto T, Takaku F, Akiyama Y (1990) In vivo effects of recombinant human interleukin-6 in primates: stimulated production of plate-lets. Blood 75: 1602–1605

    Google Scholar 

  5. Asaoku H, Kawano M, Iwato K, Tanabe O, Tanaka H, Hirano T, Kishimoto T, Kuramoto A (1988) Decrease in BSF-2/IL-6 response in advanced cases of multiple myeloma. Blood 72: 429–432

    Google Scholar 

  6. Bataille R, Jourdan M, Zhang XG, Klein B (1989) Serum levels of interleukin-6, a potent myeloma cell growth factor, as a reflection of disease severity in plasma cell dyscrasias. J Clin Invest 84: 2008–2010

    Google Scholar 

  7. Bauer J (1989) Interleukin-6 and its receptor during homeostasis, inflammation, and tumor growth. Klin Wochenschr 67: 697–706

    Google Scholar 

  8. Bauer J, Ganter U, Geiger T, Jacobshagen U, Hirano T, Matsuda T, Kishimoto T, Andus T, Acs G, Gerok W, Ciliberto G (1988) Regulation of interleukin-6 expression in cultured human blood monocytes and monocyte-derived macrophages. Blood 72: 1134–1140

    Google Scholar 

  9. Bauer J, Bauer TM, Kalb T, Taga T, Lengyel G, Hirano T, Kishimoto T, Acs G, Mayer L, Gerok W (1989) Regulation of interleukin-6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes. J Exp Med 170: 1537–1549

    Google Scholar 

  10. Bender S, Haubeck HD, Van de Leur E, Dufhues G, Schiel X, Lauweriins J, Greiling H, Heinrich PC (1990) Interleukin-1 β induces synthesis and secreation of interleukin-6 in human chondrocytes. FEBS Lett 263: 321–324

    Google Scholar 

  11. Bhardwaj N, Santhanam U, Lau LL, Tatter SB, Ghrayeb J, Rivels M, Steinmann RM, Sehgal PB, May LT (1989) IL-6/IFNβ2 in synovial effusions of patients with rheumatoid arthritis and other arthritides. J Immunol 143: 2153–2159

    Google Scholar 

  12. Biondi A, Rossi V, Bassan R, Barbui T, Bettoni S, Sironi M, Mantovani A, Rambaldi A (1989) Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia. Blood 73: 1279–1284

    Google Scholar 

  13. Bodine D, Karlsson S, Nienhuis AW (1989) Combination of interleukin-3 and -6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hemopoietic stem cells. Proc Natl Acad Sci USA 86: 8897–8901

    Google Scholar 

  14. Bot FJ, van Eijk L, Broeders L, Aarden LA, Löwenberg B (1989) Interleukin-6 synergizes with M-CSF in the formation of macrophage colonies from purified human marrow progenitor cells. Blood 73: 135–137

    Google Scholar 

  15. Brach MA, Löwenberg B, Mantovani L, Schwulera U, Brennscheidt U, Mertelsmann R, Herrmann F (1990) Interleukin-6 (IL-6) is an intermediate in IL-1-induced proliferation of leukemic human megakaryoblasts. Blood 76: 1972–1979

    Google Scholar 

  16. Brach MA, Cicco NA, Riedel D, Hirano T, Kishimoto T, Mertelsmann RH, Herrmann F (1990) Mechanisms of differential regulation of interleukin-6 mRNA accumulation by tumor necrosis factor alpha and lymphotoxin during monocytic differentiation. FEBS Lett 263: 349–354

    Google Scholar 

  17. Brandt SJ, Bodine DM, Dunbar CE, Nienhuis AW (1990) Dysregulated interleukin-6 expression produces a syndrome resembling Castleman's disease in mice. J Clin Invest 86: 592–599

    Google Scholar 

  18. Breen EC, Rezai AR, Nakajima K, Beall GN, Mitsuyasu RT, Hirano T, Kishimoto T, Martinez-Maza O (1990) Infection with HIV is associated with elevated IL-6 levels and production. J Immunol 144: 480–484

    Google Scholar 

  19. Broukaert P, Spriggs DR, Demetri G, Kufe DW, Fiers W (1989) Circulating interleukin-6 during a continuous infusion of tumor necrosis factor and interferon gamma. J Exp Med 169: 2257–2262

    Google Scholar 

  20. Caracciolo D, Clark SC, Rovera G (1989) Human interleukin-6 supports granulocyte differentiation of hematopoietic progenitor cells and acts synergistically with GM-CSF. Blood 73: 666–670

    Google Scholar 

  21. Chen L, Novick D, Rubinstein M, Revel M (1988) Recombinant interferon-β2 (interleukin-6) induces myeloid differentiation. FEBS Lett 239: 299–304

    Google Scholar 

  22. Chen L, Mory Y, Zilberstein A, Revel M (1988) Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon β2. Proc Natl Acad Sci USA 85: 8037–8041

    Google Scholar 

  23. Chiu CP, Lee F (1989) IL-6 is a differentiation factor for M1 and WEHI-3B myeloid leukemic cells. J Immunol 142: 1909–1915

    Google Scholar 

  24. Cicco NA, Lindemann A, Content J, Vandenbussche P, Lübbert M, Gauss J, Mertelsmann R, Herrmann F (1989) Inducible production of interleukin-6 by human polymorphonuclear neutrophils: role of granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. Blood 75: 2049–2052

    Google Scholar 

  25. Everson MP, Brown CB, Lilly MB (1989) Interleukin-6 and granulocyte-macrophage colony-stimulating factor are candidate growth factors for chronic myelomonocytic leukemia cells. Blood 74: 1472–1476

    Google Scholar 

  26. Fiedler W, Weh HJ, Sucin E, Wittlief C, Stocking C, Hossfeld DK (1990) The IL-6 gene but not the IL-6 receptor gene is occasionally rearranged in patients with multiple myeloma. Leukemia 4: 462–465

    Google Scholar 

  27. Fong Y, Moldawer LL, Marano M, Wei H, Tatter SB, Clarick RH, Santhanam U, Sherris D, May LT, Sehgal PB, Lowry SF (1989) Endotoxemia elicits increased circulating IFN-β2/IL-6 in man. J Immunol 142: 2321–2324

    Google Scholar 

  28. Freeman GJ, Freedman AS, Rabinowe SN, Segil JM, Horowitz J, Rosen K, Whitman JF, Nadler LM (1989) Interleukin-6 gene expression in normal and neoplastic B cells. J Clin Invest 83: 1512–1518

    Google Scholar 

  29. Frei K, Malipiero UV, Leist TP, Zinkernagel RM, Schwab ME, Fontana A (1989) On the cellular source and function of interleukin-6 in the central nervous system in viral disease. Eur J Immunol 19: 689–694

    Google Scholar 

  30. Ganter U, Arcone R, Toniatti C, Ciliberto G (1989) Dual control of CRP gene expression by interleukin-1 and interleukin-6. EMBO J 8: 3773–3779

    Google Scholar 

  31. Garman RD, Jacobs KA, Clark SC, Raulet DH (1987) B-cellstimulatory factor 2 (β2-interferon) functions as a second signal for interleukin-2 production by mature murine T cells. Proc Natl Acad Sci USA 84: 7629–7633

    Google Scholar 

  32. Grau GE (1990) Implications of cytokines in immunopathology: experimental and clinical data. Eur Cytokine Net 1: 203–210

    Google Scholar 

  33. Grossmann RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB (1989) Interleukin-6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 86: 6367–6371

    Google Scholar 

  34. Guerne PA, Carson DA, Lotz M (1990) IL-6 production by human articular chondrocytes. J Immunol 144: 499–505

    Google Scholar 

  35. Hack CE, De Groot ER, Felt-Bersma RJF, Nuijens JH, Van Schijndel RJM, Eerenberg-Belmer AJM, Thijs LG, Aarden LA (1989) Increased plasma levels of interleukin-6 in sepsis. Blood 74: 1704–1710

    Google Scholar 

  36. Helfgott DC, Tatter SB, Santhanam U, Clarick RH, Bhardwaj N, May LT, Sehgal PB (1989) Multiple forms of IFN-β2/IL-6 in serum and body fluids during acute bacterial infection. J Immunol 142: 948–953

    Google Scholar 

  37. Hibi M, Murakami M, Saito M, Hirano T, Taga T, Kishimoto T (1990) Molecular cloning and expression of an IL-6 signal transducer, gp 130. Cell 63: 1149–1157

    Google Scholar 

  38. Hill RJ, Warren MK, Levin J (1990) Stimulation of thrombopoiesis in mice by human recombinant interleukin-6. J Clin Invest 85: 1242–1247

    Google Scholar 

  39. Hirano T (1990) Interleukin-6 in immune response and hematopoiesis. In: Mertelsmann R, Herrmann F (eds) Hematopoietic growth factors in clinical applications. Marcel Dekker, New York, pp 471–488

    Google Scholar 

  40. Hirano T, Taga T, Nakano N, Yasukawa K, Kashiwamura S, Shimizu K, Nakajima K, Pyun KH, Kishimoto T (1985) Purification to homogeneity and characterization of human B-cell differentiation factor (BCDF or BSF-2). Proc Natl Acad Sci USA 82: 5490–5494

    Google Scholar 

  41. Hirano T, Taga T, Yasukawa K, Nakajima K, Nakano N, Takatsuki F, Shimizu M, Murashima A, Tsunasawa S, Sakiyama F, Kishimoto T (1987) Human B-cell differentiation factor defined by antipeptide antibody and its possible role in autoantibody production. Proc Natl Acad Sci USA 84: 228–231

    Google Scholar 

  42. Hirano T, Matsuda T, Turner M, Miyasaka N, Buchan G, Tang B, Sato K, Shimizu M, Maini R, Feldmann M, Kishimoto T (1988) Excessive production of interleukin-6/B-cell-stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol 18: 1797–1801

    Google Scholar 

  43. Hoang T, Haman A, Goncalves O, Wong GG, Clark SC (1988) Interleukin-6 enhances growth factor-dependent proliferation of the blast cells of acute myeloblastic leukemia. Blood 72: 823–826

    Google Scholar 

  44. Horii Y, Muraguchi A, Iwano M, Matsuda T, Hirayama T, Yamada H, Fuji Y, Dohi K, Ishikawa H, Ohomoto Y, Yoshizaki K, Hirano T, Kishimoto T (1989) Involvement of IL-6 in mesangial proliferative glomerulonephritis. J Immunol 143: 3949–3955

    Google Scholar 

  45. Houssiau FA, Bukasa K, Sindic CJM, Van Damme J, Van Snick J (1988) Elevated levels of the 26-K human hybridoma growth factor (interleukin-6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol 71: 320–323

    Google Scholar 

  46. Houssiau FA, Coulie PG, Olive D, Van Snick J (1988) Synergistic activation of human T cells by interleukin-1 and interleukin-6. Eur J Immunol 18: 653–656

    Google Scholar 

  47. Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai Y, Ogawa M (1987) Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci USA 84: 9035–9039

    Google Scholar 

  48. Ishibashi T (1989) Kimura H, Uchida T, Kariyone S, Friese P, Burstein SA (1989) Human interleukin-6 is a direct promoter of maturation of megakaryocytes in vitro. Proc Natl Acad Sci USA 86: 5953–5957

    Google Scholar 

  49. Ishibashi T, Kimura H, Shikama Y, Uchida T, Kariyone S, Hirano T, Kishimoto T, Takatsuki F, Akiyama Y (1989) Interleukin-6 is a potent thrombopoietic factor in vivo in mice. Blood 74: 1241–1244

    Google Scholar 

  50. Ishikawa H, Tanaka H, Iwato K, Tanabe O, Assaoku H, Nobuyoshi M, Yamamoto I, Kawano M, Kuramoto A (1990) Effect of glucocorticoids on the biological activities of myeloma cells: inhibition of interleukin-1β osteoclast activating factorinduced bone resorption. Blood 75: 715–720

    Google Scholar 

  51. Ishimi Y, Miyaura L, Jin C, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T (1990) IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145: 3297–3303

    Google Scholar 

  52. Jablons DM, Mule JJ, McIntosh JK, Sehgal PB, May LT, Huang CM, Rosenberg SA, Lotze MT (1989) IL-6/IFNβ2 as a circulating hormone. Induction by cytokine administration. J Immunol 142: 1542–1547

    Google Scholar 

  53. Jourdan M, Bataille R, Seguin J, Zhang XG, Chaptal PA, Klein B (1990) Constitutive production of interleukin-6 and immunologic features in cardiac myxoma. Arthritis Rheum 33: 398–403

    Google Scholar 

  54. Kato K, Yokoi T, Takano N, Kanegane H, Yachie A, Miyawaki T, Taniguchi N (1990) Detection by in situ hybridization and phenotypic characterization of cells expressing IL-6 mRNA in human stimulated blood. J Immunol 144: 1317–1322

    Google Scholar 

  55. Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato K, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramoto A, Kishimoto T (1988) Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332: 83–85

    Google Scholar 

  56. Kirnbauer R, Köck A, Schwarz T, Urbanski A, Krutmann J, Borth W, Damm D, Shipley G, Ansel JC, Luger TA (1989) IFNβ2, BSF-2, or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines. J Immunol 142: 1922–1928

    Google Scholar 

  57. Kishimoto T (1989) The biology of interleukin-6. Blood 74: 1–10

    Google Scholar 

  58. Klein B, Zhang XG, Jourdan M, Content J, Houssian F, Aarden L, Piechaczyk M, Bataille R (1989) Paracrine rather than autocrine regulation of myeloma — cell growth and differentiation by IL-6. Blood 73: 517–526

    Google Scholar 

  59. Klein B, Zhang XG, Jourdan M, Boiron JM, Portier M, Lu ZY, Wijdenes J, Brochier J, Bataille R (1990) Interleukin-6 is the central tumor growth factor in vitro and in vivo in multiple myeloma. Eur Cytokine Net 1: 193–201

    Google Scholar 

  60. Klein H, Becher R, Lübbert M, Oster W, Schleiermacher E, Brach MA, Souza L, Lindemann A, Mertelsmann R, Herrmann F (1990) Synthesis of granulocyte colony-stimulating factor and its requirement for terminal divisions in chronic myelogenous leukemia. J Exp Med 171: 1785–1790

    Google Scholar 

  61. Koike K, Nakahata T, Kikuchi T, Takagi M, Ishiguro A, Tsuji K, Naganuma K, Okano A, Akiyama T (1990) Interleukin-6 enhances murine megakaryocytopoiesis in serum-free culture. Blood 75: 2286–2291

    Google Scholar 

  62. Krutman J, Elmets CA (1988) Recent studies on mechanisms in photoimmunology. Photochem Photobiol 48: 787–798

    Google Scholar 

  63. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD (1990) IL-6 stimulates osteoclast-like multinucleated cell formation in long-term human marrow cultures by inducing IL-1 release. J Immunol 144: 4226–4230

    Google Scholar 

  64. Lansdorp PM, Aarden LA, Calafat J, Zeiljemaker WP (1986) A growth-factor-dependent B-cell hybridoma. Curr Top Microbiol Immunol 132: 105–113

    Google Scholar 

  65. Lee JD, Swisher SG, Minehart EH, Mc Bride WH, Economou JS (1990) Interleukin-4 down regulates interleukin-6 production in human peripheral blood mononuclear cells. J Leuk Biol 47: 475–479

    Google Scholar 

  66. Leary AG, Ikebuchi K, Hirai Y, Wong GG, Yang YC, Clark SC, Ogawa M (1988) Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha. Blood 71: 1759–1763

    Google Scholar 

  67. Lindemann A, Ganser A, Hoelzer D, Mertelsmann R, Herrmann F (1991) In vivo administration of recombinant human interleukin-3 elicits an acute phase response involving endogenous synthesis of interleukin-6. Ann Intern Med (in press)

  68. Loppnow H, Libby P (1990) Proliferating or interleukin-1-activated human vascular smooth muscle cells screte copious interleukin-6. J Clin Invest 85: 731–738

    Google Scholar 

  69. Lotem J, Shabo Y, Sachs L (1989) Regulation of megakaryocyte development by interleukin-6. Blood 74: 1545–1551

    Google Scholar 

  70. Lorre K, Van Damme J, Verwilghen J, Baroja ML, Ceuppens JL (1990) IL-6 is an accessory signal in the alternative CD2-mediated pathway of T-cell activation. J Immunol 144: 4681–4687

    Google Scholar 

  71. Lübbert M, Oster W, McComick F, Mertelsmann R, Herrmann F (1991) Clonal analysis of N-ras gene activation in acute myeloid leukemia. J Clin Invest (in press)

  72. Lübbert M, Brach M, Mertelsmann R, Herrmann F (1991) Interleukin-6 inhibits growth of plasma cell neoplasms due to suppression of endogenous interleukin-6. Blood (in press)

  73. Luger TA, Schwarz T, Krutmann J, Kirnbauer R, Neuner P, Kock A, Urbanski A, Borth W, Schauer E (1989) Interleukin-6 is produced by epidermal cells and plays an important role in the activation of human T-lymphocytes and natural killer cells: regulation of the acute phase and immune responses. Ann NY Acad Sci 557: 405–414

    Google Scholar 

  74. Luger TA, Krutman J, Kirnbauer R, Urbanski A, Schwarz T, Klappacher G, Köck A, Micksche M, Malejczyk J, Schauer E, May LT, Sehgal PB (1989) IFNβ2/IL-6 augments the activity of human natural killer cells. J Immunol 143: 1206–1209

    Google Scholar 

  75. Mantovani L, Henschler R, Brach MA, Wieser R, Lübbert M, Lindemann A, Mertelsmann R, Herrmann F (1990) Differential regulation of interleukin-6 expression in human fibroblasts by tumor necrosis factor-alpha and lymphotoxin. FEBS Lett 270: 152–156

    Google Scholar 

  76. Matsuda T, Hirano T, Kishimoto T (1988) Establishment of a interleukin-6 dependent cell line and preparation of anti-IL-6 monoclonal antibodies. Eur J Immunol 18: 951–956

    Google Scholar 

  77. Miki S, Iwano M, Miki Y, Yamamoto M, Tang B, Yokokawa K, Sonoda T, Hirano T, Kishimoto T (1989) Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal carcinomas. FEBS Lett 250: 607–610

    Google Scholar 

  78. Miles SA, Rezai AR, Salazar-Gonzales JF, Van der Meyden M, Stevens RH, Logan DM, Mitsuyasu RT, Taga T, Hirano T, Kishimoto T, Martinez-Maza O (1990) AIDS Kaposi sarcomaderived cells produce and respond to interleukin-6. Proc Natl Acad Sci USA 87: 4068–4072

    Google Scholar 

  79. Morinaga Y, Suzuki H, Takatsuki F, Akiyama Y, Taniyama T, Matsushima K, Onozaki K (1989) Contribution of IL-6 to the antiproliferative effect of IL-1 and tumor necrosis factor on tumor cell lines. J Immunol 143: 3538–3542

    Google Scholar 

  80. Moshage HJ, Roelofs HNJ, Van Pelt JF, Hazenberg BPC, Van Leewen MA, Limburg PC, Aarden LA, Yap SH (1988) The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytes. Biochem Biophys Res Comm 155: 112–117

    Google Scholar 

  81. Mule JJ, McIntosh JK, Jablons DM, Rosenberg SA (1990) Antitumor activity of recombinant interleukin-6 in mice. J Exp Med 171: 629–636

    Google Scholar 

  82. Musso T, Espinoza-Delgado J, Pulkki K, Gussela GL, Longo DL, Varesio L (1990) Transforming growth factor beta downregulates interleukin-1-induced IL-6 production by human monocytes. Blood 76: 2466–2469

    Google Scholar 

  83. Nagasawa T, Orita T, Matsushita J, Tsuchiya M, Neichi T, Imazeki I, Imai N, Ochi N, Kanma H, Abe T (1990) Thrombopoietic activity of human interleukin-6. FEBS Lett 260: 176–178

    Google Scholar 

  84. Nijsten MWN, De Groot ER, Ten Duis HJ, Klasen HJ, Hack CE, Aarden LA (1987) Serum levels of interleukin-6 and acute phase responses. Lancet 2: 921

    Google Scholar 

  85. Oster W, Cicco NA, Klein H, Hirano T, Kishimoto T, Lindemann A, Mertelsmann R, Herrmann F (1989) Participation of the cytokines interleukin-6, tumor necrosis factor-alpha, and interleukin-1-beta secreted by acute myelogenous leukemia blasts in autocrine and paracrine leukemia growth control. J Clin Invest 84: 451–457

    Google Scholar 

  86. Poli G, Bressler P, Kinter T, Duh E, Timmer WC, Rabson A, Justement S, Stanley S, Fauci AS (1990) Interleukin-6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor alpha by transcriptional and posttranscriptional mechanisms. J Exp Med 172: 151–158

    Google Scholar 

  87. Pullicino EA, Carli F, Poole S, Rafferty B, Malik STA, Elia M (1990) The relationship between the circulating concentrations of interleukin-6 (IL-6), tumor necrosis factor (TNF) and the acute phase response to elective surgery and accidental injury. Lymphok Res 9: 2–6

    Google Scholar 

  88. Rennick D, Jackson J, Yang G, Wideman J, Lee F, Hudak S (1989) Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythoid, myeloid and multipotential progenitor cells. Blood 73: 1828–1835

    Google Scholar 

  89. Revel M, Chen L, Novivk D, Shulman LM, Gotthelf Y, Cohen B, Raber J, Chebath J, Michaelevicz R (1990) The growthpromoting, differentiative and cytostatic properties of interleukin-6. Proc Am Assoc Canc Res 31: 499–505

    Google Scholar 

  90. Romero R, Avila C, Santhanam U, Sehgal PB (1990) Amniotic fluid interleukin-6 in preterm labor. J Clin Invest 85: 1392–1400

    Google Scholar 

  91. Rose-John S, Schooltink H, Lenz D, Hipp E, Dufhues G, Schmitz H, Schiel X, Hirano T, Kishimoto T, Heinrich PC (1990) Studies on the structure and regulation of the human hepatic interleukin-6 receptor. Eur J Biochem 190: 79–83

    Google Scholar 

  92. Sachs L, Lotem J, Shabo Y (1989) The molecular regulators of macrophage and granulocyte development. Ann NY Acad Sci 557: 417–437

    Google Scholar 

  93. Shabo Y, Lotem J, Sachs L (1989) Autoregulation of interleukin-6 and granulocyte-macrophage colony-stimulating factor in the differentiation of myeloid leukemia cells. Mol Cell Biol 9: 4109–4112

    Google Scholar 

  94. Shenkin A, Fraser WD, Series J, Winstanley FP, McCartney AC, Burns HJG, Van Damme J (1989) The serum interleukin-6 response to elective surgery. Lymphok Res 8: 123–127

    Google Scholar 

  95. Siegall CB, Chaudhary VK, Fitzgerald DJ, Pastan I (1988) Cytotoxic activity of an interleukin-6-Pseudomonas exotoxin fusion protein on human myeloma cells. Proc Natl Acad Sci USA 85: 9738–9742

    Google Scholar 

  96. Sironi M, Breviario F, Proserpio P, Biondi A, Vecchi J, Van Damma E, Mantovani A (1989) IL-1 stimulates IL-6 production in endothelial cells. J Immunol 142: 549–553

    Google Scholar 

  97. Smyth MJ, Ortaldo JR, Bere W, Yagita H, Okumura K, Young HA (1990) IL-2 and IL-6 synergize to augment the pore-forming protein gene expression and cytotoxic potential of human peripheral blood T cells. J Immunol 145: 1159–1166

    Google Scholar 

  98. Suzuki C, Okano A, Takatsuki F, Miyasaka Y, Hirano T, Kishimoto T, Ejima D, Akiyama Y (1989) Continuous perfusion with interleukin-6 enhances production of hematopoietic stem cells (CFU-S). Biochem Biophys Res Commun 159: 933–938

    Google Scholar 

  99. Bender S, Haubeck HD, Van de Leur E, Dufhues G, Schiel X, Lauweriins J, Greiling H, Heinrich PC (1990) Interleukin-1 β induces synthesis and secreation of interleukin-6 in human chondrocytes. FEBS Lett 263: 321–324

    Google Scholar 

  100. Tabibzadeh SS, Poubouridis D, May LT, Sehgal PB (1991) Interleukin-6 immunoreactivity in human tumors. Am J -Pathol (in press)

  101. Tamm I, Cardinale I, Krueger J, Murphy JS, May LT, Sehgal PB (1989) Interleukin-6 decreases cell-cell association and increases motility of ductal breast carcinoma. J Exp Med 170: 1649–1669

    Google Scholar 

  102. Te Velde AA, Huijbens RJF, Heije K, des Vries JE, Figdor CG (1990) Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor-alpha and IL-6 by monocytes. Blood 76: 1392–1397

    Google Scholar 

  103. Tosato G, Miller J, Marti G, Pike SE (1990) Accessory function of interleukin-1 and interleukin-6: preferential costimulation of T4-positive lymphocytes. Blood 75: 922–930

    Google Scholar 

  104. Utsumi K, Takai Y, Tada T, Ohzeki S, Fujiwara H, Hamaoka T (1990) Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production. J Immunol 145: 397–403

    Google Scholar 

  105. van der Schoot CE, Jansen P, Poorter M, Wester MR, Kr. von dem Borne AEG, Aarden LA, von Oers RHJ (1989) Interleukin-6 and interleukin-1 production in acute myeloid leukemia with monocytoid differentiation. Blood 74: 2081–2087

    Google Scholar 

  106. van Oers MHJ, van der Heyden AAPAM, Aarden LA (1988) Interleukin-6 (IL-6) in serum and urine of renal transplant recipients. Clin Exp Immunol 71: 314–319

    Google Scholar 

  107. van Snick J, Cayphas S, Vink A, Uyttenhove C, Coulie PG, Rubira MR, Simpson RJ (1986) Purification and NH2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci USA 83: 9679–9684

    Google Scholar 

  108. Yasukawa K, Hirano T, Watanabe Y, Murutoni K, Matsuda T, Nakai S, Kishimoto T (1987) Structure and expression of human B-cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J 6: 2939–2945

    Google Scholar 

  109. Yoshizaki K, Nakagawa T, Fukunaga K, Tseng LT, Yamamura Y, Kishimoto T (1984) Isolation and characterization of B-cell differentiation factor (BCDF) secreted from a human B lymphoblastoid cell line. J Immunol 132: 2948–2954

    Google Scholar 

  110. Yoshizaki K, Matsuda T, Nishimoto N, Kuritani T, Taeho L, Aozasa K, Nakahate T, Kawai H, Tagoh H, Komori T, Kishimoto S, Hirano T, Kishimoto S (1989) Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood 74: 1360–1367

    Google Scholar 

  111. Zhang XG, Klein B, Bataille R (1989) Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma. Blood 74: 11–13

    Google Scholar 

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  1. Psychiatrische Universitätsklinik und Medizinische Universitätsklinik (Abteilung Innere Medizin 1), Universität Freiburg, W-7800, Freiburg, FRG

    J. Bauer & F. Herrmann

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  1. J. Bauer
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  2. F. Herrmann
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Bauer, J., Herrmann, F. Interleukin-6 in clinical medicine. Ann Hematol 62, 203–210 (1991). https://doi.org/10.1007/BF01729833

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  • DOI: https://doi.org/10.1007/BF01729833

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