Summary
Experimental diabetes can be cured by intraportal transplantation of isolated islets of Langerhans (investigations in inbred rats). Late complications such as nephropathy or retinopathy can be inhibited or even reversed at least in early stages. Allogeneic islets are highly immunogenic. Immunogenicity can be reduced by cultivation of fetal islets. Islet banking seems to be possible by cryopreservation. First islet transplantations in human diabetics led to reduced doses of insulin. Autologous reimplantation has been performed after pancreatectomy in some cases of chronic relapsing pancreatitis.
Zusammenfassung
Ein experimenteller Diabetes kann durch Transplantation isolierter Langerhansscher Inseln geheilt werden (ingezüchtete Ratten). Diabetische Spästkomplikationen (Nieren, Auge) können verhindert werden bzw. in Frühstadien sogar zurückgebildet werden. Im allogenen System sind isolierte Inseln hoch immunogen. Eine Inselbank kann durch Kryopräservation angelegt werden. Eine Reduzierung der Immunogenität durch die Kultivierung fetaler Inseln erscheint möglich. Erste Versuche einer Inseltransplantation beim Menschen führten zu einer Reduktion des Insulinbedarfs. Eine autologe Reimplantation wurde in einigen wenigen Fällen bei Pankreatektomie wegen chronisch rezidivierender Pankreatitis durchgeführt.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Ballinger, W. F., Lacy, P. E.: Transplantation of intact pancreatic islets in rats. Surgery72, 175 (1972)
Bretzel, R. G., Breidenbach, Ch., Hofmann, J., Federlin, K.: Islet transplantation in experimental diabetes of the rat. VI. Rate of regression in diabetic kidney lesions after isogeneic islet transplantation: Quantitative measurements. Horm. Metab. Res. (im Druck)
Dobroschke, J., Schwemmle, K., Langhoff, G., Laube, H., Bretzel, R. G., Federlin, K.: Autotransplantation von Langerhansschen Inseln nach totaler Duodenopankreatektomie bei einem Patienten mit chronischer Pankreatitis. Dtsch. Med. Wochenschr.103, 1905 (1978)
Federlin, K., Bretzcl, R. G., Schmidtchen, U.: Islet transplantation in experimental diabetes of the rat. V. Regression of glomerular lesions on diabetic rats after intraportal transplantation of isogeneic islets. Preliminary results. Horm. Metab. Res.8, 404 (1976)
Federlin, K., Helmke, K., Slijepcevic, M., Pfeiffer, E. F.: Transplantation of isolated islets of Langerhans into pancreatectomized rats (Abstract). Diabetologia9, 66 (1973)
Gliedmann, M. L., Tellis, V. A., Soberman, R., Rifkin, H., Veith, F. J.: Long-term effects of pancreatic transplant function in patients with advanced juvenile onset diabetes. Diabetes Care1, 1 (1978)
Hegre, O. D., Leonard, R. J., Schmitt, R. V., Lazarov, A.: Osp transplantation of organic cultured neonatal pancreas: Reversal of alloxan diabetes in the rat. Diabetes25, 180 (1976)
Kedinger, M., Moody, A., Lanny, I. F., Haffer, K.: Establishment of serum based medium essentially free of proteolytic activity for the culture of mouse pancreatic islets. Experientia33, 972 (1972)
Lacy, P. E., Kostianovsky, M.: Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes16, 35 (1976)
Lafferty, K. J., Cooley, M. A., Woolnough, J., Walker, K. Z.: Thyroid allograft immunogenicity is reduced after a period in organ culture. Science188, 259 (1975)
Mandl, T.: persönliche Mitteilung 1979
Mauer, S. M., Steffes, M. W., Sutherland, D. E. R., Najarian, J. S., Michael, A. F., Brown, D. M.: Studies of the rate of regression of the glomerular lesions on diabetic rats treated with pancreatic islet transplantation. Diabetes24, 280 (1975)
Najarian, J. S., Sutherland, D. E. R., Matas, A. J., Steffes, M. W., Simmons, R. L., Goetz, F. C.: Human islet transplantation: A preliminary report. Transplant. Proc.2/9, 233 (1977)
Nielsen, J. H., Brunstedt, J., Andersson, A., Frimodt-Møller, C.: Preservation of beta cell function in adult human pancreatic islets for several mopths in vitro. Diabetologia16, 97 (1979)
Orloff, M. J., Lee, S., Charters, A. C., Grambort, D. E., Storck, L. G., Knox, D.: Long-term studies of pancreas transplantation in experimental diabetes mellitus. Ann. Surg.182, 259 (1975)
Pipeleers, D. G., Pipeleers-Marichal, M. A., Kari, I. E., Kipnis, D. M.: Secretory capability of islets transplanted intraportally in the diabetic rat. Diabetes27, 817 (1978)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Federlin, K., Bretzel, R.G., Schneider, J. et al. 35. Neue Aspekte in der Diabetes-Behandlung: Inselzelltransplantation. Langenbecks Arch Chiv 349, 177–182 (1979). https://doi.org/10.1007/BF01729492
Issue Date:
DOI: https://doi.org/10.1007/BF01729492