Summary
Anaerobic bacteremia was studied in 32 medical patients (mean age 72 years) in a four-year retrospective analysis. Malignancy was the most common underlying disease and probable portal of entry. The gastrointestinal tract was affected most often, followed by the respiratory and urinary tracts. Bacteremia occurred either following invasive (non surgical) procedures or spontaneously. The clinical course ranged from asymptomatic bacteremia, to mild febrile illness, to sepsis and septic shock (two, 12, 16 and two patients, respectively). The case fatality rate was 25%. The causative organisms wereClostridium andBacteroides species. All organisms isolated were susceptible to chloramphenicol. Early diagnosis and prompt treatment may reduce mortality in cases of anaerobic sepsis.
Zusammenfassung
In einer retrospektiven Studie, die einen Zeitraum von vier Jahren erfaßte, wurden 32 Fälle von anaerober Bakteriämie bei Patienten der Inneren Medizin (mittleres Alter 72 Jahre) entdeckt. Als häufigste Grundkrankheiten fanden sich Malignome, vor allem des Gastrointestinaltraktes, aber auch der Atemwege und des Harntraktes. Sie dürften zugleich die Eintrittspforte für die Infektionen sein. Bakteriämien traten entweder nach invasiven (nicht chirurgischen) Eingriffen oder spontan auf. Die klinischen Bilder reichten von einer asymptomatischen Bakteriämie über leichte fieberhafte Erkrankungen bis zur Sepsis und zum septischen Schock. Diese Krankheitsbilder fanden sich jeweils bei zwei, 12, 16 und zwei Patienten. Die Mortalität lag bei 25%. Als kausale Erreger wurdenClostridium undBacteroides Spezies identifiziert. Alle Isolate waren empfindlich gegen Chloramphenicol. Durch Frühdiagnose und Soforttherapie könnte es möglich sein, die Letalität der Sepsis durch anaerobe Erreger zu senken.
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Kornowski, R., Schwartz, D., Averbuch, M. et al. Anaerobic bacteremia: A retrospective four-year analysis in general medicine and cancer patients. Infection 21, 241–244 (1993). https://doi.org/10.1007/BF01728898
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DOI: https://doi.org/10.1007/BF01728898