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Serum concentrations of interferon gamma, interleukin-6 and neopterin in patients with infectious mononucleosis and other Epstein-Barr virus-related lymphoproliferative diseases

Serumkonzentrationen von Interferon γ, Interleukin-6 und Neopterin bei Patienten mit infektiöser Mononukleose und anderen Epstein-Barr Virus-assoziierten lymphoproliferativen Erkrankungen

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Summary

Serum levels of interferon γ, interlcukin-6 and neopterin were determined in 15 patients with different forms of Epstein-Barr virus-associated diseases: acute self-limiting infectious mononucleosis, chronic active infectious mononucleosis and X-linked lymphoproliferative syndrome. In patients with acute type of infection, neopterin, interferon γ and interleukin-6 were elevated in nearly all patients. In contrast, the situation was less clear-cut in the other EBV-associated diseases; particularly interleukin-6 was undetectable in most cases. The results suggest that concomitant measurement of these diverse immune activation markers may provide interesting insights into the interactions between the virus and the host, and may also lead to therapeutic consequenes.

Zusammenfassung

Interferon γ, Interleukin-6 und Neopterin wurden in Serumproben von 15 Patienten mit verschiedenen Formen Epstein-Barr Virus-assoziierter Erkrankungen gemessen: Bei akuter selbstlimitierender infektiöser Mononukleose, bei chronisch aktiver infektiöser Mononukleose und bei X-chromosomal gebundenem lymphoproliferativem Syndrom. Bei fast allen Patienten mit einer Infektion vom akuten Typ waren alle drei Immunaktivie-rungsmarker erhöht. Bei den anderen Erkrankungsformen war die Situation weniger einheitlich; insbesondere Interleukin-6 war bei diesen Patienten kaum erhöht. Die Ergebnisse weisen darauf hin, daß eine simultane Bestimmung dieser unterschiedlichen Immunaktivierungs-marker interessante Einblicke in das Wechselwirkungsgefüge zwischen dem Virus und dem Patientenorganismus zulassen und vielleicht auch zu therapeutischen Konsequenzen führen kann.

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Authors and Affiliations

  1. Kinderklinik der Universität Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    V. Schuster M. D.

  2. Klinik für Innere Medizin der Universität Innsbruck, Anichstr. 35, A-6020, Innsbruck, Austria

    M. Herold M. D., Ph. D.

  3. Institut für Medizinische Chemie und Biochemie der Universität Innsbruck, Fritz-Pregl-Str. 3, A-6020, Innsbruck, Austria

    H. Wachter Ph. D. &  G. Reibnegger D. Sc.

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Schuster, V., Herold, M., Wachter, H. et al. Serum concentrations of interferon gamma, interleukin-6 and neopterin in patients with infectious mononucleosis and other Epstein-Barr virus-related lymphoproliferative diseases. Infection 21, 210–213 (1993). https://doi.org/10.1007/BF01728890

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  • DOI: https://doi.org/10.1007/BF01728890

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