Virus Genes

, Volume 11, Issue 2–3, pp 183–190 | Cite as

Analysis of the phylogenetic placement of different spumaretroviral genes reveals complex pattern of foamy virus evolution

  • Holger Warnat Dias
  • Mordechai Aboud
  • Rolf M. Flügel
Part B: Molecular Processes Involved In The Evolution Of RNA And DNA Viruses


Foamy or spumaviruses are complex retroviruses. Phylogenetic trees have been constructed previously for either the polymerase or integrase domains showed a clustering of the foamy viruses relatively distant from other retroviruses. The most related retrovirus was found to be murine leukemia virus, irrespective of the method used or foamy viral gene analyzed. We analyzebel genes of different foamy viruses and compared the corresponding phylogenetic trees with those obtained from thepol genes that were constructed with refined computer programs. In addition, the nucleocapsid protein sequence of foamy viruses was used for a comparative phylogenetic analysis. Known biological properties of the individual FV protein domains are discussed to ascertain the apparent phylogenetic relatedness.

Key words

foamy virus spumavirus retrovirus Bel genes pol nucleocapsid protein phylogenetic analysis 


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Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • Holger Warnat Dias
    • 1
  • Mordechai Aboud
    • 1
    • 2
  • Rolf M. Flügel
    • 1
  1. 1.Abteilung Retroviral GenexpressionForschungsschwerpunkt Angewandte Tumorvirologie, DKFZ, InF 242HeidelbergFRG
  2. 2.Dept. of MicrobiologyBen-Gurion University of NégevBeershevaIsrael

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