Klinische Wochenschrift

, Volume 65, Issue 3, pp 113–120 | Cite as

Funktionen der körpereigenen Abwehr gegen Anaerobier bei Gesunden und Patienten mit chronisch-septischer Granulomatose

  • A. Wildfeuer
  • R. Dopfer
  • D. Niethammer
  • J. Galle
  • H. Laufen
  • O. Haferkamp
  • E. Vanek
Originalien
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Abkürzungen

NBT

Nitroblautetrazolium

B. fragilis

Bacteroides fragilis

Function of the defense system against anaerobes in healthy volunteers and patients with chronic granulomatous disease

Summary

Different strains ofBacteroides fragilis exhibit great differences in sensitivity towards serum from healthy volunteers. In the presence of 10% autologous serum, neutrophilic granulocytes and monocytes (macrophages) caused significant killing ofB. fragilis. The measured phagocytic and killing activity of the cells is comparable to their activity against aerobic bacteria (S. aureus). In four patients with chronic granulomatous disease of childhood, phagocytosis was normal but killing ofB. fragilis andS. aureus in granulocytes or monocytes (macrophages) was appreciably lowered. This malfunction of the cells was accompanied by a disturbance in oxidative metabolism and inadequate iodination after phagocytosis ofB. fragilis. The results suggest that granulocytes and monocytes play an important role in host defense against endogenous infections with anaerobes.

Key words

Anaerobic infections Bacteroides Defense mechanisms Chronic granulomatous disease 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Wildfeuer
    • 3
  • R. Dopfer
    • 2
  • D. Niethammer
    • 2
  • J. Galle
  • H. Laufen
  • O. Haferkamp
  • E. Vanek
    • 1
  1. 1.Abteilung für Pathologie sowie Sektion für Infektionskrankheiten der Universität UlmGermany
  2. 2.Abteilung für Pädiatrische HämatologieKinderklinik der Eberhard-Karls-Universität TübingenGermany
  3. 3.Heinrich Mack Nachfolger Forschung und EntwicklungIlltertissen

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