Klinische Wochenschrift

, Volume 66, Issue 5, pp 187–189 | Cite as

Acute regulation of lymphocyteβ-adrenoceptor activity in pheochromocytoma

  • M. Middeke
  • G. Lohmöller
  • J. Remien
  • S. Kirzinger
  • H. Holzgreve


The effect of an acute endogeneous catecholamine stimulation on the regulation of lymphocyteβ-adrenoceptor activity was studied in a patient with pheochromocytoma. Baseline blood pressure, heart rate, adrenoceptor density, and plasma concentrations of epinephrine, norepinephrine, and cyclic adenosine monophosphate were normal. Excessive spontaneous increases of catecholamine concentrations were accompanied by a rise in blood pressure, bradycardia, and an acute up-regulation ofβ-adrenoceptors. Plasma concentrations of cyclic adenosine monophosphate paralleled the increase in receptor density and blood pressure. After normalization of catecholamine plasma levels, blood pressure, andβ-adrenoceptor density returned to baseline values. This observation adds support to the theory that an acute catecholamine stimulation leads to an acute sensitization of theβ-adrenoceptor-adenylatecyclase-cyclic-adenosine-monophosphate system leading to blood pressure elevation.

Key words

Pheochromocytoma β2-Adrenoceptors in pheochromocytoma 



maximal binding sites per cell


cyclic-adenosine monophosphate




heart rate


dissociation constant


mean arterial blood pressure




β-adrenoceptor-adenyl-atecyclase-cAMP system


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • M. Middeke
    • 1
  • G. Lohmöller
    • 1
  • J. Remien
    • 2
  • S. Kirzinger
    • 1
  • H. Holzgreve
    • 1
  1. 1.Medizinische Poliklinik, Universität MünchenGermany
  2. 2.Walther-Straub-Institut für Pharmakologie und Toxikologie Universität MünchenGermany

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