Klinische Wochenschrift

, Volume 66, Issue 5, pp 187–189 | Cite as

Acute regulation of lymphocyteβ-adrenoceptor activity in pheochromocytoma

  • M. Middeke
  • G. Lohmöller
  • J. Remien
  • S. Kirzinger
  • H. Holzgreve
Originalien

Summary

The effect of an acute endogeneous catecholamine stimulation on the regulation of lymphocyteβ-adrenoceptor activity was studied in a patient with pheochromocytoma. Baseline blood pressure, heart rate, adrenoceptor density, and plasma concentrations of epinephrine, norepinephrine, and cyclic adenosine monophosphate were normal. Excessive spontaneous increases of catecholamine concentrations were accompanied by a rise in blood pressure, bradycardia, and an acute up-regulation ofβ-adrenoceptors. Plasma concentrations of cyclic adenosine monophosphate paralleled the increase in receptor density and blood pressure. After normalization of catecholamine plasma levels, blood pressure, andβ-adrenoceptor density returned to baseline values. This observation adds support to the theory that an acute catecholamine stimulation leads to an acute sensitization of theβ-adrenoceptor-adenylatecyclase-cyclic-adenosine-monophosphate system leading to blood pressure elevation.

Key words

Pheochromocytoma β2-Adrenoceptors in pheochromocytoma 

Abbreviations

Bmax

maximal binding sites per cell

cAMP

cyclic-adenosine monophosphate

E

epinephrine

HR

heart rate

KD

dissociation constant

MAP

mean arterial blood pressure

NE

norepinephrine

βAAS

β-adrenoceptor-adenyl-atecyclase-cAMP system

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References

  1. 1.
    Brodde OE, Bock KD (1984) Changes in platelet alpha2-adrenoceptors in human pheochromocytoma. Eur J Clin Pharmacol 26:265–267Google Scholar
  2. 2.
    Chobanian AV, Tifft CP, Sackel H, Pitruzella A (1982) Alpha and beta adrenergic receptor activity in circulating blood cells of patients with idiopathic orthostatic hypotension and pheochromocytoma. Clin Exp Hypertens A 4:793–806Google Scholar
  3. 3.
    Davies IB, Sudera D, Sever PS (1981) Endogenous agonist regulation of alpha-adrenoceptors in man. Clin Sci 61:207s-210sGoogle Scholar
  4. 4.
    Middeke M, Remien J, Block LH, Kirzinger S, Landrock A, Holzgreve H (1983) Beta2-adrenoceptor density on membranes and on intact mononuclear cells in essential hypertension. Res Exp Med 183:227–232Google Scholar
  5. 5.
    Middeke M, Remien J, Holzgreve H (1984) The influence of sex, age, blood pressure and physical stress onβ 2-adrenoceptor density of mononuclear cells. J Hypertens 2:261–264Google Scholar
  6. 6.
    Middeke M, Kirzinger S, Remien J, Krahl B, Holzgreve H (1986) An altered acute regulation of theβ-adrenoceptor-adenylatecyclase system in patients with essential hypertension at rest and under exercise. Clin Exp Hypertens A 8,1:135–136Google Scholar
  7. 7.
    Schalekamp MADH, Vincent HH, Man in't Veld AJ (1983) Adrenaline, stress, and hypertension. Lancet I:362Google Scholar
  8. 8.
    Snavely MD, Mahan LC, O'Connor DT, Insel PA (1983) Selective down-regulation of adrenergic receptor subtypes in tissues from rats with pheochromocytoma. Endocrinology 113:354–361Google Scholar
  9. 9.
    Tohmeh JF, Cryer PE (1980) Biphasic adrenergic modulation ofβ-adrenergic receptors in man. J Clin Invest 65:836–840Google Scholar
  10. 10.
    Tsujimoto G, Manger WM, Hoffman BB (1984) Desensitization ofβ-adrenergic receptors by pheochromocytoma. Endocrinology 114:1271–1278Google Scholar

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • M. Middeke
    • 1
  • G. Lohmöller
    • 1
  • J. Remien
    • 2
  • S. Kirzinger
    • 1
  • H. Holzgreve
    • 1
  1. 1.Medizinische Poliklinik, Universität MünchenGermany
  2. 2.Walther-Straub-Institut für Pharmakologie und Toxikologie Universität MünchenGermany

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