Klinische Wochenschrift

, Volume 64, Issue 8, pp 362–365 | Cite as

Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy

  • N. Niederle
  • J. Schütte
  • C. G. Schmidt
Originalien

Summary

Twenty nonseminomatous testicular cancer patients not pretreated with emetogenic chemotherapy were included in a crossover study of antiemetic therapy. Patients were randomly assigned to receive either nabilone (2×2 mg/day) or alizapride (3×150 mg/day) prior to beginning lowdose cisplatin chemotherapy. Patients on nabilone had significantly fewer episodes of emesis than those on alizapride (medians, 1.1 vs 2.9;p<0.01). Nabilone was superior to alizapride in giving complete relief from nausea (medians, 65% vs 30%;p<0.01), and was more effective in shortening the duration of nausea (medians, 1.3 h vs 5.1 h;p<0.01); however, it caused more adverse effects. It is concluded that nabilone has greater antiemetic activity than alizapride in young patients receiving low-dose cisplatin chemotherapy. Nabilone dosage should be reduced to decrease the incidence and degree of adverse reactions while leaving the definite antiemetic activity unchanged.

Key words

Antiemetic therapy Alizapride Cisplatin Nabilone 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • N. Niederle
    • 1
  • J. Schütte
    • 1
  • C. G. Schmidt
    • 1
  1. 1.Innere Universitätsklinik und Poliklinik (Tumorforschung), Westdeutsches TumorzentrumEssen

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