Summary
In an open, randomized prospective clinical trial the analgesic effect of indomethacin and ketobemidon was compared in 67 patients with acute cholecystitis (28 received 5 mg ketobemidon and 39 received 50 mg indomethacin). Both drugs showed a good and significant pain relief, exhibiting no significant difference in the analgesic effect and no serious adverse reactions. It was concluded that indomethacin administered intravenously is an alternative to ketobemidon intravenously in the treatment of pain resulting from acute cholecystitis and may offer some advantages.
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Abbreviations
- NSAID:
-
Non-Steroidal-Anti-Inflammatory-Drugs
- SI:
-
Schmerzintensität
- SL:
-
Schmerzlinderung
- SR:
-
Schmerzreduktion
- SD:
-
Standard deviation
- 99m-Tc-HIDA:
-
99m-Technetium-2.6-dimethyl-acetanilide-iminodiacetic acid
Literatur
Csendes A, Sepulveda A (1980) Intraluminal Gallbladder Pressure Measurements in Patients With Chronic or Acute Cholecystitis. Am J Surg 139:383–384
Jansson R, Thornell E, Svanvik J (1983) Effects of Indomethacin on Gallbladder Pressure in Patients with Acute Cholecystitis. Scand J Urol Nephrol Suppl 75:51–53
Jönsson P-E, Erichsen C, Holmin T, Petersson B-Å (1985) Double Blind Evaluation of Intravenous Indomethacin and Oxycone-Papaverin in the Treatment of Acute Biliary Pain. Acta Chir Scand (In press)
Kantor, TG (1982) Control of Pain by Nonsteroidal Anti-Inflammatory Drugs. Med Clin N Am 66:1053–1059
Marsala F (1980) Treatment of Ureteral and Biliary Pain with an Injectible Salt of Indomethacin. Pharmacotherapeutica 2:357–362
Maxwell C (1978) Sensitivity and Accuracy of the Visual Analogue Scale. Br J Clin Pharmacol 6:15–24
Niinikoski J, Nelimarkka O, Pekkola P (1984) Intravenous Indomethacin in Biliary Pain. Ann Chir Gynaecol 73:69–72
Quiding H, Häggquist S-O (1983) Visual Analogue Scale and the Analysis of Analgesic Action. Eur J Clin Pharmacol 24:475–478
Sjödahl R, Tagesson C (1983) On the Development of Primary Acute Cholecystitis. Scand J Gastroenterol 18:577–579
Sjödin JG (1984) Clinical Experience of Indomethacin in Pain from Ureteral Stone. Scand J Urol Nephrol Suppl 75:35–36
Sjödin JG, Holmlund D (1982) Indomethacin Administrated intravenously in the Treatment of Ureteral Colic. A Multicenter Study. Scand J Urol Nephrol 16:221–225
Svanvik J, Thornell E, Zettergren L (1981) Gallbladder Function in Experimental Cholecystitis. Surgery 89:500–506
Thornell E (1982) Mechanisms in the development of Acute Cholecystitis and Biliary Pain. A Study on the Role of Prostaglandins and Effect of Indomethacin. Scand J Gastroenterol Suppl 76:1–31
Thornell E, Jansson R, Svanvik J (1981) Indomethacin Intravenously — A New Way for Effective Relief of Biliary Pain. A Double Blind Study in Man. Surgery 90:468–472
Udén P, Starck C-J, Berger TA (1984) Comparison of Indomethacin and Dihydromorphinone in Acute, Biliary Stone Pain. Curr Therapeut Res 36:1228–1234
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Mätzsch, T., Holmlund, D. Vergleich von Indometacin und Ketobemidon als Analgetikum bei akuter Cholecystitis. Klin Wochenschr 64, 353–356 (1986). https://doi.org/10.1007/BF01728182
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DOI: https://doi.org/10.1007/BF01728182