Literatur
Ahnfelt-Ronne I, Haagen Nielsen O (1987) The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. Agents Actions 21:191–194
Allgayer H, Stenson WF (1988) Role of lipoxygenase pathway products in an anmal model of colitis: effect of pretreatment with 5-lipoxygenase inhibitors. Gastroenterology 94:A6
Campieri M, Lanfranchi GA, Bazzochi G, Brignola C, Benatti A, Boccia S, Labo G (1980) Prostaglandins, indomethacin, and ulcerative colitis. Gastroenterology 78:193
Gilat T, Ratan J, Rosen P, Peled J (1979) Prostaglandins and ulcerative colitis. Gastroenterology 77:1083
Higgs GA, Moncada S, Vane JR (1984) Eicosanoids in inflammation. Ann Clin Res 16:287–299
Hoult JRS (1986) Pharmacological and biochemical actions of sulphasalazine. Drugs 32 (Suppl 1):18–26
Lauritsen K, Hansen J, Ryde M, Rask-Madsen J (1984) Colonic azodisalicylate metabolism determined by in vivo dialysis in healthy volunteers and patients with ulcerative colitis. Gastroenterology 86:1496–1500
Lauritsen K, Laursen LS, Bukhave K, Rask-Madsen J (1986) Effects of topical 5-aminosalicylic acid and prednisolone on prostaglandin E2 and leukotriene B4 levels determined by equilibrium in vivo dialysis of rectum in relapsing ulcerative colitis. Gastroenterology 91:837–844
Lobos EA, Sharon P, Stenson WF (1987) Chemotactic activity in inflammatory bowel disease: role of leukotriene B4. Dig Dis Sci 32:1380–1388
MacNaughton WK, Morris GP, Wallace JL (1988) Inhibition of leukotriene synthesis markedly enhances healing in a rat model of inflammatory bowel disease. Gastroenterology 94:A618
Montzka DM, Smith PL, Fondacaro JD (1987) Action of peptidoleukotrienes (PLTs) on electrolyte transport in rat small intestine. Gastroenterology 92:1803
Peskar BM, Dreyling KW, Peskar BA, May B, Goebell H (1986) Enhanced formation of sulfidopeptide-leukotrienes in ulcerative colitis and Crohn's disease: inhibition of sulfasalazine and 5-aminosalicylic acid. Agent Actions 18:381–383
Peskar BM, Dreyling KW, May B, Schaarschmidt K, Goebell H (1987) Possible mode of action of 5-aminosalicylic acid. Dig Dis Sci 32:51S-56S
Rampton DS, Hawkey CJ (1984) Prostaglandins and ulcerative colitis. Gut 25:1399–1413
Rampton DS, MacNeil NI, Sarner M (1983) Analgesic ingestion and other factors preceding relapse in ulcerative colitis. Gut 24:187–189
Rampton DS, Sladen GE (1981) Prostaglandin synthesis inhibitors in ulcerative colitis: Flurbiprofen compared with conventional treatment. Prostaglandins 21:417–425
Saverymuttu SH, Peters AM, Lavender JP, Chadwick VS, Hodgson HJ (1985) In vivo assessment of granulocytic migration to diseased bowel in Crohn's disease. Gut 26:378–383
Schlenker T, Peskar BM (1981) Dual effect of sulphasalazine on colonic prostaglandin synthetase. Lancet 2:815
Sharon P, Stenson WF (1984) Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 86:453–460
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Peskar, B.M. Hemmung der intestinalen Leukotrien-Bildung als mögliches Wirkprinzip von Sulfasalazin, 5-Aminosalizylsäure und 4-Aminosalizylsäure. Klin Wochenschr 66, 1147–1150 (1988). https://doi.org/10.1007/BF01727854
Issue Date:
DOI: https://doi.org/10.1007/BF01727854