Summary
Several granulocyte functions were analyzed in vitro in 154 patients with chronic or recurrent infections, as well as in a variety of disorders known or suspected to affect host resistance. Only a few specific abnormalities were diagnostic and occurred in congenital, hereditary disorders. Opposed to these permanent changes are those which were probably acquired or transient and are often multifactorial in origin. In the majority of these patients, an inconstant and nonspecific pattern emerged which is not helpful in the diagnosis of underlying disease. In selected patients, however, and as research procedures, these and related tests should be helpful in elucidating the basic functions of granulocytes and may implicate therapeutical approaches.
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Bültmann B, Geitner R, Seibold H, Kratzsch G, Haferkamp O (1980) Interaction of circulating immune complexes with granulocyte function in patients with rheumatoid arthritis. Klin Wochenschr 58:727–732
Bültmann B, Eggers HJ, Haferkamp O (1981) Selective inhibition of human neutrophil chemotaxis by Echo virus, type 9. Klin Wochenschr 59:571–573
Bültmann B, Melzner I, Haferkamp O, Gruler H (1982) Changes in membrane fluidity of human neutrophilic granulocytes exposed to a chemoattractant (FMLP) and Echo virus, type 9, strain A. Barty. Acta Histochem (Jena) (in press)
Christou N, Meakins J (1979) Neutrophil function in surgical patients: two inhibitors of granulocyte chemotaxis associated with sepsis. J Surg Res 26:355–364
Haas RJ, Niethammer D, Flad HD, Wildfeuer A, Bültmann B, Haferkamp O, Kleihauer E (1976) A case of impaired chemotaxis and lymphocyte transformation. Acta Paediatr Scand 65:241–247
Haferkamp O, Heymer B, Schachenmayr W, Bültmann B (1974) Serumabhängige Funktionsstörungen von Granulozyten. Dtsch Med Wochenschr 99:182–189
Higby D (1981) Granulocyte transfusions: where now? N Engl J Med 305:636–638
Hill HR, Quie PG (1974) Raised serum-IgG levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet I:183–187
Klebanoff SJ, Clark RA (1978) The neutrophil: function and clinical disorders. North Holland Publ Amsterdam
Kramer N, Perez HD, Goldstein IM (1980) An immunoglobulin (IgG) inhibitor of polymorphonuclear leukocyte motility in a patient with recurrent infection. N Engl J Med 303:1253–1258
Lehrer RJ, Cline MB (1969) Interaction of Candida albicans with human leucocytes and serum. J Bacteriol 89:896–902
Mandell GL, Hook EW (1969) Leukocytic function in chronic granulomatous disease of childhood. Am J Med 47:473–479
Mowat AG, Baum J (1971) Chemotaxis of polymorphonuclear leucocytes from patients with rheumatoid arthritis. J Clin Invest 50:2541–2549
Niethammer D, Wildfeuer A, Kleihauer E, Haferkamp O (1975) Granulozytendysfunktion I. Angeborene Störungen. Klin Wochenschr 53:643–648
Niethammer D, Wildfeuer A, Kleihauer E, Haferkamp O (1975) Granulozytenfunktion II. Erworbene Störungen. Klin Wochenschr 53:739–744
Niethammer D, Heinze E, Teller W, Kleihauer E, Wildfeuer A, Haferkamp O (1975) Impairment of granulocyte function in juvenile diabetes. Klin Wochenschr 53:1057–1060
Niethammer D, Wildfeuer A, Bültmann B, Haferkamp O, Kleihauer E (1979) Problems of the correlation between test results of granulocyte function and the diseases. In: Kobubun Y, Kobayashi N (eds) Phagocytosis: Its physiology and pathology. University of Tokyo Press, Tokyo
Oliver JM (1978) Cell biology of leukocyte abnormalities. Am J Pathol 93:221–260
Pflieger H, Arnold R, Bhaduri S, Bültmann B, Goldmann SF, Haghou F, Kubanek B, Kurrle E, Niethammer D (1979) Beneficial effect of granulocyte transfusion in patients with defects in granulocyte function and severe infections. Scand J Haematol 22:33–41
Preisig E, Hitzig WH (1971) Nitroblue-tetrazolium test for the detection of chronic granulomatous disease-technical modification. Eur J Clin Invest 1:409–412
Saunders SJ, Dowdle EB, Fiskerstrand C, Bassendine M, Walls R (1978) Serum factors affecting neutrophil function during acute viral hepatitis. Gut 19:930–934
Seger R, Wildfeuer A, Buchinger G, Römer W, Catty D, Dybas L, Haferkamp O, Ströder J (1976) Defects in granulocyte function in various chromosome abnormalities. Klin Wochenschr 54:735–742
Senn HJ (1978) Störungen der Leukozytenfunktion. Methodik der Untersuchung und klinische Aspekte. In: Löhr GW, Arnold H, Engelhardt R, Möbius W (eds): Problem der Erythropoese, Granulocytopoese und des malignen Melanoms. Springer, Berlin Heidelberg New York, pp 341–353
Strauss R, Connett J, Gale R, Bloomfield C, Herzig G, McCullough J, Maguire L, Winston D, Ho W, Stump D, Miller W, Koepke J (1981) A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogeneous leukemia. N Engl J Med 305:597–603
Theophilopoulos AN, Wilson CB, Dixon FR (1976) The Raji cell racioimmune assay for detecting immune complexes in human sera. J Clin Invest 57:169–182
Valone FH (1980) Modulation of human neutrophil and eosinophil polymorphonuclear leucocyte chemotaxis: an analytic review. Clin Immunol Immunpathol 15:52–65
Zubler RH, Nydegger U, Perrin LH, Fehr K, McCormick J, Lambert PH, Miescher PA (1976) Circulating and intraarticular immune complexes in patients with rheumatoid arthritis. J Clin Invest 57:1308–1319
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Bültmann, B., Wildfeuer, A., Schindlbeck, U. et al. Critical analysis of granulocyte function in 154 patients with different diseases. Klin Wochenschr 60, 1289–1295 (1982). https://doi.org/10.1007/BF01727485
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DOI: https://doi.org/10.1007/BF01727485