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Lupus anticoagulant associated syndrome in benign and malignant systemic disease

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Summary

A strong correlation exists between the presence of an in vitro plasma coagulation inhibitor, named “lupus anticoagulant”, and a clinical syndrome of recurrent arterial and venous thromboses, neurological abnormalities, repeated obstetrical complications, thrombocytopenia, a biologic false-positive serological test for syphilis, and a variety of rarer manifestations. This syndrome has predominantly been observed in patients with autoimmune diseases, but it may be of similar importance in association with monoclonal gammopathies. As an introduction to a detailed analysis of ten observations which will also be published in this journal, this article reviews the clinical findings, the proposed pathogenetic mechanisms and the approaches to management of the lupus anticoagulant associated syndrome.

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Abbreviations

aPTT:

Activated partial thromboplastin time

BFP-STS:

Biologic false-positive serological test for syphilis

DNA:

Deoxyribonucleic acid

LA:

Lupus anticoagulant

LP immunocytoma:

Lymphoplasmacytoid immunocytoma

PT:

Prothrombin time

SLE:

Systemic lupus erythematosus

VDRL:

Venereal Disease Research Laboratory

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Authors and Affiliations

  1. Medizinische Klinik und Poliklinik der Universität (GHS) Essen, Germany

    U. Dührsen, D. Paar & G. Brittinger

  2. The Walter and Eliza Hall Institute of Medical Research Cancer Research Unit, The Royal Melbourne Hospital, Post Office, 3050, Victoria, Australia

    U. Dührsen

Authors
  1. U. Dührsen
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  2. D. Paar
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  3. G. Brittinger
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Additional information

This paper is dedicated to Professor Dr. Karl Lennert on the occasion of his 65th birthday

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Dührsen, U., Paar, D. & Brittinger, G. Lupus anticoagulant associated syndrome in benign and malignant systemic disease. Klin Wochenschr 65, 818–822 (1987). https://doi.org/10.1007/BF01727476

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  • DOI: https://doi.org/10.1007/BF01727476

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