Klinische Wochenschrift

, Volume 62, Issue 19, pp 931–935 | Cite as

Erfolgreiche Behandlung der Kappa-Leichtketten-Nephropathie durch Membranplasmaseparation (MPS)

  • K. B. G. Sprenger
  • J. Galle
  • I. Sprenger-Klasen
  • J. M. Herrmann
  • H. E. Franz

Successful treatment of kappa light chain nephropathy by membrane plasma separation


Often the diagnosis “light chain nephropathy” is not made before renal failure has developed. In the past these patients had a poor prognosis. Special features of this disease and improvement of renal function by plasma exchange therapy are shown in a case report. A 51-year-old man admitted to hospital with renal failure, proteinuria and hypercalcaemia was treated by Ca-free dialysis and membrane plasma separation (MPS). Renal biopsy studied by light and electron microscopy showed mainly tubular protein casts. It is assumed that this nephropathy is caused by a direct toxic effect of the kappa light chains on function and structure of tubuli. Proteinuria was markedly lowered and renal failure was made partly reversible by prompt and effective MPS. Thus, MPS may improve the prognosis of this stage of disease.

Key words

Kappa light chain nephropathy Plasma exchange therapy Membrane plasma separation Calcium-free dialysis 


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Copyright information

© Springer-Verlag 1984

Authors and Affiliations

  • K. B. G. Sprenger
    • 1
  • J. Galle
    • 2
  • I. Sprenger-Klasen
    • 1
  • J. M. Herrmann
    • 3
  • H. E. Franz
    • 1
  1. 1.Sektion Nephrologie, Abt. Innere Medizin IGermany
  2. 2.Abteilung für PathologieGermany
  3. 3.Abteilung für Psychosomatik der Universität UlmGermany

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