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Monozygote Zwillinge mit Klinefelter-Syndrom (konkordant) und systemischem Lupus erythematodes (diskordant)

Monozygotic twins with klinefelter's syndrome (concordant) and systemic lupus erythematosus (discordant)

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Summary

Monozygotic twins, both with Klinefelter's syndrome, are presented. One of them had clinical and serological evidence of systemic lupus erythematosus (SLE), whereas the other did not show any immunological disorder. In relation to this case of discordant SLE the role played by exogenous factors in triggering the manifestation of this autoimmune disease under a certain genetic predisposition is discussed.

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Abbreviations

KS:

Klinefelter-Syndrom

SLE:

Systemischer Lupus erythematodes

CRP:

C-reaktives Protein

ANA:

Antinukleäre Antikörper

SK-SD:

Streptokinase-Streptodornase

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Authors and Affiliations

  1. Abteilung Humangenetik im Klinikum der Christian-Albrechts-Universität Kiel, Germany

    B. Schlegelberger & W. Grote

  2. I. Medizinische Klinik der Christian-Albrechts-Universität Kiel, Germany

    T. Schlegelberger, J. Kekow & W. L. Gross

Authors
  1. B. Schlegelberger
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  2. T. Schlegelberger
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  3. J. Kekow
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  4. W. L. Gross
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  5. W. Grote
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Schlegelberger, B., Schlegelberger, T., Kekow, J. et al. Monozygote Zwillinge mit Klinefelter-Syndrom (konkordant) und systemischem Lupus erythematodes (diskordant). Klin Wochenschr 62, 906–910 (1984). https://doi.org/10.1007/BF01727439

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  • DOI: https://doi.org/10.1007/BF01727439

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