Klinische Wochenschrift

, Volume 67, Issue 20, pp 1061–1065 | Cite as

Unusually rapid development of a HBsAG-positive liver cirrhosis after liver transplantation

  • H. -U. Lautz
  • R. Müller
  • C. Wittekind
  • S. Mauz
  • H. Barg-Hock
  • B. Ringe
  • R. Pichlmayr
  • F. W. Schmidt
Case Report


We report the case of a 44-year-old man who was transplanted in 1986 for hepatocellular carcinoma in a HBsAG-positive liver cirrhosis. The patient had no severe complications postoperatively. He received passive immunization for the prevention of hepatitis B reinfection during the first 6 months after liver grafting. Twelve months after the transplantation the new liver was reinfected with hepatitis B virus. Without any clinical or laboratory signs of severe hepatitis, the patient developed a histologically proven complete liver cirrhosis within 8 months after reinfection of the graft. The reasons for this might have been, first, a deleterious course of the infection under immunosuppressive therapy, and, second, the additional influence of a postoperatively acquired CMV infection or the combined toxic influence of cyclosporin A and its metabolites on the acute inflammation in the liver.

Key words

Liver cirrhosis Liver transplantation Hepatitis B 



Alanine aminotransferase (EC No


Aspartate aminotransferase (EC No


Cytomegalo virus


Ebstein-Barr virus


Enzyme linked immunosorbentassay


Hepatitis B virus


Human leukocyte antigen


Herpes simplex virus


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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • H. -U. Lautz
    • 1
  • R. Müller
    • 1
  • C. Wittekind
    • 2
  • S. Mauz
    • 3
  • H. Barg-Hock
    • 3
  • B. Ringe
    • 3
  • R. Pichlmayr
    • 3
  • F. W. Schmidt
    • 1
  1. 1.Abteilung Gastroenterologie u. Hepatologie im Zentrum Innere Medizin und DermatologieGermany
  2. 2.Pathologisches InstitutGermany
  3. 3.Klinik für Abdominal- und Transplantationschirurgie Medizinische Hochschule HannoverGermany

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