Klinische Wochenschrift

, Volume 65, Issue 13, pp 625–626 | Cite as

“In vitro” improvement of defective monocyte chemotaxis in intravenous drug abusers after incubation with ascorbic acid

  • A. J. Lopez
  • D. G. Palomo
  • J. L. P. Castrillon
  • J. L. P. Arellano
Wissenschaftliche Kurzmitteilung

Summary

Intravenous drug abusers have a deficit of monocyte chemotaxis. “In vitro” ascorbic acid restores the impaired chemotaxis.

Key words

Monocyte Chemotaxis Ascorbic acid Intravenous drug abusers 

Abbreviations

CI

Chemotactic index

EAS

Endotoxin-activating serum

IDA

Intravenous drug abusers

PBM

Peripheral blood monocytes

References

  1. 1.
    Boxer LA, Watanave AM, Rister M et al. (1976) Correction of leukocyte function in Chediak-Higashi syndrome by ascorbate. N Engl J Med 295:1041–1045Google Scholar
  2. 2.
    Brown SM, Stimmel B, Taub RN, Koch WAS, Rosenfield R (1974) Immunologic dysfunction in heroin addicts. Arch Intern Med 134:1001–1006Google Scholar
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    Cherubin CE (1971) Infectious disease problems of narcotic addicts. Arch Intern Med 128:309–313Google Scholar
  4. 4.
    Gallin JI, Sandler JA, Clyman RI, Manganiello VC, Vaughan M (1978) Agents that increase cyclic AMP inhibit accumulation of cGMP and depress human monocyte locomotion. J Immunol 120:492–496Google Scholar
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    Poli G, Bottazi B, Acero R et al. (1985) Monocyte function in intravenous drug abusers with lymphadenopathy syndrome and in patients with acquired immunodeficiency syndrome: selective impairment of chemotaxis. Clin Exp Immunol 62:136–142Google Scholar
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    Poli G, Introna M, Zanaboni F et al. (1985) Natural killer cells in intravenous drug-abusers with lymphadenopathy syndrome. Clin Exp Immunol 62:128–135Google Scholar
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    Snyderman R, Altman LC, Harsman Ms, Mergenhager SH (1972) Human mononuclear leucocyte chemotaxis: a quantitative assay for humoral and cellular chemotactic factors. J Immunol 108:857–860Google Scholar

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. J. Lopez
    • 1
  • D. G. Palomo
    • 1
  • J. L. P. Castrillon
    • 1
  • J. L. P. Arellano
    • 1
  1. 1.Departmento de Patologia General Hospital Clinico Universitario SalamancaSpain

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