Summary
To examine alterations of the kallikrein-kinin system and of the complement due to the bolus injection of newer non-ionic contrast agents, venous blood samples were taken before and 3 min after angiography. There were no adverse contrast reactions clinically evident. Prekallikrein, kallikrein inhibition, β-factor XIIa inhibition, C1-esterase inhibitor, C1q, C3, ATIII, HMW-kininogen, fibrinogen and faktor XII were determined.
Bolus injection of the contrast medium caused an activation of the kallikrein-kinin system (p<0.05) with reduction of prekallikrein, kallikrein-inhibition, β-factor XIIa inhibition and C1-esterase inhibitor. The levels of C1q and C3 were also decreased (p<0.05) indicating an activation of the complement.
Our results demonstrate, that angiography causes a significant activation of the kallikrein-kinin as well as of the complement system in spite of the use of newer non-ionic contrast agents.
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Hoffmeister, H.M., Fuhrer, G., Pirschel, J. et al. Veränderungen des Kallikrein-Kinin-und des Komplement-Systems bei Angiographien mit nicht-ionischen Kontrastmitteln. Klin Wochenschr 66, 760–763 (1988). https://doi.org/10.1007/BF01726572
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DOI: https://doi.org/10.1007/BF01726572