Summary
A seroepidemiological study was carried out in order to determine the prevalence of markers of viral hepatitis infection in employees of five health-care companies and their cohabiting family members. Each participating family unit was required to fill out a questionnaire, in which, among other data, the employee was requested to indicate his or her job category. Markers of hepatitis B infection (anti-HBs, anti-HBc or HBsAg) were observed in 11.7% (58/497) of all subjects. When employees and family members were analysed according to the employee's job category, significant differences were found between “staff” (3%) and “administrative personnel” (13.3%; p<0.01) or “factory workers” (16.9%; p<0.01). Of 489 individuals tested for the presence of anti-HAV and anti- HCV, 59.1% and 0.6% respectively, were positive. There was a correlation between the prevalence of anti-HAV and age; a large proportion of the subjects under the age of 30 years had no evidence of prior HAV infection.
Zusammenfassung
Um die Prävalenz von Virus-Hepatitis-Markern zu ermitteln, wurde eine seroepidemiologische Studie durchgeführt, in die Beschäftigte von fünf pharmazeutischen Firmen und Familienmitglieder der Wohngemeinschaft aufgenommen wurden. Fragebogen, die alle teilnehmenden Familien auszufüllen hatten, enthielten unter anderem Daten zur Berufsbezeichnung. 58 von 497 untersuchten Seren (11,7%) wiesen Marker einer Hepatitis B Virus-Infektion auf (anti-HBs, anti-HBc oder HBsAg). Nach Berufskategorie aufgeschlüsselt, fanden sich zwischen Beschäftigten und Familienmitgliedern signifikante Unterschiede: Personen, die zum Staff gehörten, waren in 3% der Fälle positiv, Verwaltungspersonal in 13,3% (p<0,01), Fabrikarbeiter in 16,9% (p<0,01). Von den 489 auf anti- HAV getesteten Personen waren 59,1 % positiv, anti-HCV-Antikörper wiesen in derselben Gruppe 0,6% der Getesteten auf. Die Prävalenz von anti-HAV zeigte eine Altersabhängigkeit; ein großer Anteil der unter 30jährigen hatte keine Marker für eine durchgemachte HAV-Infektion.
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References
Genesca, J., Esteban, J. I., Esteban, R., Buti, M., Muñiz, R., Seijo, G., Hernández, J. M., Guardia, J. Difusión intrafamiliar del virus de la Hepatitis B. Estudio de contactos familiares de portadores crónicos. Med. Clin. (Barc). 87 (1986) 271–274.
Centers for Disease Control Protection against viral hepatitis. Recommendations of the Immunization Practices Advisory Committee (ACIP). MMWR 39 No RR-2 (1990) 5–23.
Vargas, V., Esteban, R., Pedreira, J. M., Viladoms, J., Hernández, J. M., Guardia, J. Anti-hepatitis A antibody in Spain. Lancet ii (1978) 583.
Vargas, V., Buti, M., Hernandez Sánchez, J. M., Jarchi, R., Portell, A., Esteban, R., Guardia, J. Prevalencia de anticuerpos contra el virus de la Hepatitis A en población general. Estudio comparativo 1977–1985. Med. Clin. (Barc) 88 (1987) 144–146.
Esteban, J. I., Esteban, R., Viladomiu, L., López-Tavera, J. C., González, A., Hernandez, J. M., Roget, M., Vargas, V., Genesca, J., Buti, M., Guardia, J., Houghton, M., Choo, Q.-L., Kuo, G. Hepatitis C virus antibodies among risk groups in Spain. Lancet ii (1989) 294–297.
Bruix, J., Barrera, J. M., Calvet, X., Ercilla, G., Costa, J., Sánchez-Tapias, J. M., Ventura, M., Vall, M., Bruguera, M., Bru, C., Castillo, R., Rodes, J. Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet ii (1989) 1004–1008.
Ruiz, M., García, J., Carreño, V., Alvarez, L., Rincon, P., López-Linares del Prado, M., Bas, C. Prevalencia de Hepatitis por virus A, B y D en niños. An. Esp. Pediatr. 29 (1988) 357–362.
Vargas, V., Pedreira, J. M., Esteban, R., Hernández, J. M., Piqueras, J., Guardia, J. Marcadores serológicos del virus de la Hepatitis B en población sana. Med. Clin. (Barc) 78 (1982) 265–267.
Vargas, V., Hernández Sánchez, J., Viladoms, J., Esteban, R., Pedeira, J. D., Guardia, J., Bacordi, R. Distribución del anticuerpo frente al antígeno de la Hepatitis A (Anti VHA) en la población general. Med. Clin. (Barc) 73 (1979) 274–276.
Anónimo Estrategia de la vacunación antihepatitis B en el personal hospitalario. Gastroenterología y Hepatología 10 (1987) 188–190.
San Miguel, G., Ortiz de Diego, R., Cabero, M. J., Fernández-Felgueroso, E., Carrasco, J. L., Lardinois, R., Pons Romero, F. Actitud del personal de alto riesgo ante una campaña de vacunación antihepatitis B en un hospital general. Med. Clin. (Barc) 90 (1988) 369–373.
McQuillan, G. M., Townsend, T. R., Fields, H. A., Carroll, M., Leahy, M., Polk, P. F. Seroepidemiology of hepatitis B virus infection in the United States. Am. J. Med. 87 (Suppl 3A) (1989) 5S-10S.
Robinson, W. S. Hepatitis B virus and hepatitis delta virus. In:Mandell, G. L., Douglas, R. G., Bennett, J. E. (eds.): Principles and practice of infectious diseases. Churchill Livingstone Inc., New York 1990, pp. 1204–1231.
Cherubin, C. E., Purcell, R. H., Landers, J. J., McGinn, T. G., Cone, L. A. Acquisition of antibody to hepatitis B antigen in three socioeconomically different medical populations. Lancet ii (1972) 149–151.
Carreño García, V., González Alonso, R., Porres Cubero, J., Ortiz Mallorens, F., Martin Calderin, F., Hernández Guio, C. Prevalencia de anti HAV en la población española. Rev. Esp. Enf. Ap. Digest. 64 (1983) 187–190.
Szmuness, W., Dienstag, J. L., Purcell, R. H., Harley, E. J., Stevens, C. E., Wong, D. C. Distribution of antibody to hepatitis A antigen in urban adult population. N. Engl. J. Med. 295 (1976) 755–759.
Dienstag, J. L., Szmuness, W., Stevens, C. E., Purcell, R. H. Hepatitis A virus infection: New insights from seroepidemiologic studies. J. Infect. Dis. 137 (1978) 328–340.
Janot, C., Couroucé, A. M., Maniez, M. Antibodies to hepatitis C virus in French blood donors. Lancet ii (1989) 796–797.
Sirchia, G., Bellobuono, A., Giovanetti, A., Marconi, M. Antibodies to hepatitis C virus in Italian blood donors. Lancet ii (1989) 797.
Hess, G., Massing, A., Rossol, S., Schutt, H., Clemens, R., Meyer zum Büschenfelde, K. H. Hepatitis C virus and sexual transmission. Lancet ii (1989) 987.
Contreras, M., Barbara, J. A. J. Screening for hepatitis C virus. Lancet ii (1989) 505.
Hoofnagle, J. H. Acute viral hepatitis. In:Mandell, G. L., Douglas, R. G., Bennet, J. E. (eds.): Principles and practice of infectious disease. Churchill Livingstone Inc., New York 1990, pp. 1001–1017.
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Dal-Ré, R., Aguilar, L. & Coronel, P. Current prevalence of hepatitis B, A and C in a healthy Spanish population. A seroepidemiological study. Infection 19, 409–413 (1991). https://doi.org/10.1007/BF01726451
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DOI: https://doi.org/10.1007/BF01726451