Summary
Blood and cerebrospinal fluid (CSF) concentrations of cefmenoxime were determined either microbiologically or by means of HPLC in 20 children with proven or suspected bacterial meningitis. Sixteen children suffered from bacterial meningitis: causative organisms wereHaemophilus influenzae type b (n=10),Streptococcus pneumoniae (n=4) andNeisseria meningitidis (n=2). In these patients the cefmenoxime concentration in the CSF ranged from 0.9 to 12.2 mg/l, with a mean concentration of 4.63 mg/l 1.5–3 h after the last intravenous cefmenoxime application and 24–48 h after initiating therapy with 200 mg cefmenoxime/kg/d in four doses. In eight cases the bactericidal titers of the CSF were examined during therapy. Titers between 1:64 and 1:2,048, exceeding the minimal bactericidal concentration, were found. After five doses of cefmenoxime 50 mg/kg, two CSF cultures showed bacterial growth: oneH. influenzae (bactericidal titer in CSF 1:256) and oneS. pneumoniae.
Zusammenfassung
Bei zwanzig Kindern wurden Serum- und Liquorspiegel von Cefmenoxim mittels HPLC oder aber mikroskopisch bestimmt. Sechzehn Kinder litten an bakterieller Meningitis:Haemophilus influenzae Typ b (n=10),Streptococcus pneumoniae (n=4),Neisseria meningitidis (n=2). Die Proben wurden 24–48 h nach Behandlungsbeginn (200 mg cefmenoxim/kg/die) in vier Einzeldosen 1,5–3 h nach der letzten Gabe entnommen. Die Liquorspiegel bei den Kindern mit entzündeten Meningen lagen zwischen 0,9 bis 12,2 mg/l, im Mittel 4,63 mg/l. In acht Fällen wurde die Liquorbakterizidie bestimmt. Die Titer lagen zwischen 1:64 bis 1:2048. Zwei Liquorkulturen nach fünf Dosen 50 mg/kg zeigten bakterielles Wachstum. Einmal fand sichH. influenzae (Liquorbakterizidie 1:256) und einmalS. pneumoniae.
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Eicken, A., Schröder, J.G., Roos, R. et al. Cerebrospinal fluid penetration of cefmenoxime in children with bacterial meningitis. Infection 19, 406–408 (1991). https://doi.org/10.1007/BF01726450
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DOI: https://doi.org/10.1007/BF01726450