Abstract
This survey included 1250 tetrads from 19 families heterozygous for at least three genes on chromosome V. A number of tests were used for the detection of interference. The Papazian tests (table 1) indicated that either positive chromosomal interference or negative chromatid interference occurs in some regions; this effect is too weak to be manifest in individual families. Although chromosomal interference was not evident in the three-point tests of any one family, there was some evidence from lumped data that it occurs. Negative chromatid interference is clearly evident in the three-point tetrad data. This effect varies from family to family, and does not appear to be localized to certain regions. The data indicate that chromatid interference is a property conferred by the specific hybrid rather than a fixed property of any given chromosomal region. In this connection it is interesting to note that family 118, which exhibits chromatid interference, was obtained from a intraascal hybrid from family 108, which also shows chromatid interference, suggesting that this family-specific effect may be hereditary.
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References
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This work has been supported by the Americal Cancer Society.
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Desborough, S., Shult, E.E. An assay for chromosomal and chromatid interference in chromosome V ofSaccharomyces . Genetica 33, 69–78 (1963). https://doi.org/10.1007/BF01725749
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DOI: https://doi.org/10.1007/BF01725749