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Elektronenmikroskopische Untersuchungen über die Wirkung von Stilbamidin auf Plasmocytomzellen

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Zusammenfassung

Die Einschlußkörper, die in Plasmocytomzellen nach Stilbamidinbehandlung auftreten, wurden elektronenmikroskopisch untersucht. Die Einschlüsse haben einen Durchmesser bis zu 1,5 µ und sind von einer Membran umgeben. Sie zeigen eine polymorphe Innenstruktur. Einige enthalten Zellorganellen wie Mitochondrien und rauhes endoplasmatisches Reticulum mit Abbauerscheinungen, während andere im einzelnen beschriebene Strukturen aufweisen. Da in ihnen elektronenmikroskopisch Aktivität von saurer Phosphatase nachweisbar ist, handelt es sich um Lysosomen. Die verschiedenen Strukturen in den Einschlüssen sind wahrscheinlich unterschiedliche Abbaustufen einer partiellen Autodigestion von Zellorganellen, die durch Stilbamidin in Plasmacytomzellen hervorgerufen wird.

Summary

The inclusion bodies, which appear in plasmocytoma cells after treatment with stilbamidine, are studied by electron microscope. The inclusion bodies have a diameter up to 1,5 µ and are enclosed by a membrane. They show a polymorphic contents. Some bodies, contain organelles like mitochondria and rough endoplasmic reticulum with signs of degradation, while others contain structures, which are described indetail. The inclusion bodies show a positive reaction of acid phosphatase, therefore they are lysosomes. The different structures within the inclusions are probably different stages of degradation of partial autodigestion caused by stilbamidine in plasmocytoma cells.

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Authors and Affiliations

  1. II. Anatomisches Institut der Freien Universität Berlin, Germany

    D. Graf Keyserlingk

  2. I. Innere Abteilung des Städt. Krankenhauses Berlin-Neukölln, Germany

    I. Boll

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  1. D. Graf Keyserlingk
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Graf Keyserlingk, D., Boll, I. Elektronenmikroskopische Untersuchungen über die Wirkung von Stilbamidin auf Plasmocytomzellen. Klin Wochenschr 47, 197–201 (1969). https://doi.org/10.1007/BF01725676

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