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Leberfunktion von Patienten mit arterieller Hypoxämie bei chronisch obstruktiver Atemwegserkrankung und der Einfluß der nasalen Sauerstoffinsufflation

Liver function in patients with arterial hypoxemia and chronic obstructive airway disease and the influence of nasal oxygen insufflation

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Summary

Patients suffering from chronic obstructive airway disease often have arterial hypoxemia, which is more or less severe. If hypoxemia deteriorates the function of the liver is still unknown. The aim of this study was to determine, if a mostly oxygen dependent process of liver metabolism (galactose elimination capacity) is disturbed and if it can be increased by oxygen insufflation. Under the same conditions an oxygen independent process (indocyaninegreen clearance) should not be influenced. Our results show, that galactose elimination capacity under room air was pathologic and can be increased significantly by oxygen breathing. No change of indocyaninegreen clearance was seen under the same conditions. After termination of oxygen therapy the galactose elimination capacity was as bad as before oxygen breathing. Dysfunctions of the liver, which are caused by hypoxemia, can be positively influenced by oxygen, but only for the duration of oxygen insufflation.

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Abbreviations

Adm:

Mitteldruck im rechten Vorhof

CHE:

Cholinesterase

Gamma-GT:

Gamma-Glutamyl-Transferase

GEK:

Galaktose-Eliminations-Kapazität

ICG-HWZ:

Indocyaningrün-Halbwertzeit

KG:

Körpergewicht

NAD:

Nicotinsäureamid

NADH2 :

reduziertes Nicotinsäureamid

O2 :

molekularer Sauerstoff

pCO2a :

arterieller Kohlensäurepartialdruck

pO2a :

arterieller Sauerstoffpartialdruck

SGOT:

Serum-Glutamat-Oxalacetat-Transaminase

SGPT:

Serum-Glutamat-Pyruvat-Transaminase

SO2a :

arterielle Sauerstoffsättigung

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Authors and Affiliations

  1. Abteilung für Gastroenterologie und Hepatologie der Medizinischen Universitätsklinik Bergmannsheil, Bochum

    G. H. Micklefield, H. -D. Kuntz & B. May

  2. Medizinische Universitätsklinik Bergmannsheil, Bochum

    D. Schött & W. T. Ulmer

Authors
  1. G. H. Micklefield
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  2. D. Schött
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  3. H. -D. Kuntz
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  4. B. May
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  5. W. T. Ulmer
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Micklefield, G.H., Schött, D., Kuntz, H.D. et al. Leberfunktion von Patienten mit arterieller Hypoxämie bei chronisch obstruktiver Atemwegserkrankung und der Einfluß der nasalen Sauerstoffinsufflation. Klin Wochenschr 67, 833–838 (1989). https://doi.org/10.1007/BF01725200

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  • DOI: https://doi.org/10.1007/BF01725200

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