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Plasma-Katecholamin-Verlauf bei Alkylphosphat-Intoxikationen und deren Therapie

Plasma catecholamine kinetics in the course of organophosphate-poisonings and their therapy

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Summary

In connection with the “endogenous acetylcholine-poisoning” due to organophosphorous compounds beside the clinical important muscarinic and nicotinic symptoms an activation of the sympathetic nervous system (adrenal medulla, sympathetic ganglia) is expected. Therefore a kinetic profile of norepinephrine and epinephrine in the plasma of two patients with severe parathionpoisonings was taken up through the whole period of the intensive-medical treatment. The method used was HPLC with electrochemical detection. The parathion-concentration of the same plasma samples were measured, too. The result were individual different courses with periodically appearing, markedly increased plasma catecholamine values. A direct correlation of catecholamines with the parathion-concentration was not recognizable. A possible influence of the atropine-treatment as well as of stress-factors is discussed but estimated as not responsible for the observed peaks.

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Abbreviations

Amp.:

Ampulle

ChE:

Cholinesterase

HPLC:

High pressure liquid chromatography (Hochdruckflüssig-Chromatographie)

Li:

Lithium

m-Rezeptoren:

muskarinische Rezeptoren

n-Rezeptoren:

nikotinische Rezeptoren

®:

eingetragenes Warenzeichen

ZVD:

Zentraler Venendruck

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Authors and Affiliations

  1. Institut für Rechtsmedizin der Universität München, Germany

    G. Kauert & B. Schoppek

  2. Toxikologische Abteilung des Klinikums rechts der Isar der Technischen Universität München, Germany

    M. v. Clarmann & A. Hibler

Authors
  1. G. Kauert
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  2. B. Schoppek
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  3. M. v. Clarmann
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  4. A. Hibler
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Kauert, G., Schoppek, B., v. Clarmann, M. et al. Plasma-Katecholamin-Verlauf bei Alkylphosphat-Intoxikationen und deren Therapie. Klin Wochenschr 67, 456–462 (1989). https://doi.org/10.1007/BF01725143

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  • DOI: https://doi.org/10.1007/BF01725143

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