Virus Genes

, Volume 10, Issue 1, pp 85–90 | Cite as

HTL V-I from Iranian Mashhadi Jews in Israel is phylogenetically related to that of Japan, India, and South America rather than to that of Africa and Melanesia

  • Masahiro Yamashita
  • Anat Achiron
  • Tomoyuki Miura
  • Jun Takehisa
  • Eiji Ido
  • Tatsuhiko Igarashi
  • Kentaro Ibuki
  • Mitsuhiro Osame
  • Shunro Sonoda
  • Eldad Melamed
  • Masanori Hayami
  • Batya Shohat
Article

Abstract

A new endemic focus of human T-lymphotropic virus type I (HTL V-I) was recently reported among Mashhadi Jews, a group of immigrants from northeastern Iran to Israel. We extracted DNAs from fresh peripheral blood mononuclear cells (PBMCs) and/or gargle mouthwash from 10 HTL V-I carriers, who consisted of members of one family, and HTL V-I-associated myelopathy (HAM) and adult T-cell leukemia (ATL) patients. Long terminal repeat (LTR) regions of proviral DNAs were sequenced and analyzed phylogenetically. In a phylogenetic tree, all the Mashhadi HTL V-I isolates belonged to subtype A, one of the three subtypes of the cosmopolitan type of HTL V-I, and made a tight cluster distinct from the other isolates of subtype A from Japan, India, the Caribbean Basin, and South America. Although a few nucleotide substitutions were observed among the clones sequenced, no characteristic sequence variation was found in different disease manifestations, even in one family or different sources of DNA preparation.

Key words

HTL V-I Mashhadi Jews saliva phylogenetic analysis 

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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Masahiro Yamashita
    • 1
  • Anat Achiron
    • 2
  • Tomoyuki Miura
    • 1
  • Jun Takehisa
    • 1
  • Eiji Ido
    • 1
  • Tatsuhiko Igarashi
    • 1
  • Kentaro Ibuki
    • 1
  • Mitsuhiro Osame
    • 4
  • Shunro Sonoda
    • 4
  • Eldad Melamed
    • 2
  • Masanori Hayami
    • 1
  • Batya Shohat
    • 3
  1. 1.Laboratory of Pathogenic Virus, Institute for Virus ResearchKyoto UniversityKyotoJapan
  2. 2.Neurology DepartmentBeilinson Medical CenterPetah-TiquvaIsrael
  3. 3.Cellular Immunology UnitBeilinson Medical CenterPetah-TiquvaIsrael
  4. 4.Faculty of MedicineKagoshima UniversityKagoshimaJapan

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