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Superoxid-Dismutase und Superoxid-Radikal-Freisetzung bei juveniler rheumatoider Arthritis

Superoxide-dismutase and superoxide-radical-release in rheumatoid arthritis

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Summary

Polymorphonuclear leukocytes (PMNs) release superoxide anion (O −2 ) when they are exposed to a phagocytic stimulus. Intracellulary the copper-containing enzyme superoxide dismutase (SOD) protects against the toxic effects of O −2 . To investigate the role of O −2 and SOD in the inflammatory process we determined the O −2 -release and SOD content in PMNs. In PMNs of children with rheumatoid arthritis the SOD activity was diminished compared to healthy controls. Upon stimulation with opsonized zymosan PMNs obtained from children with rheumatoid arthritis generated greater amounts of superoxide anion than control cells. The “SOD deficiency” in PMNs of children with rheumatoid arthritis may promote this extreme release of the toxic superoxid radical inducing the damage of the connective tissue. The involvement of superoxide dismutase and superoxide anion in inflammatory process may induce further studies, leading hopefully to an appropriate understanding or even to new principles in the treatment of the rheumatoid arthritis.

Zusammenfassung

Granulozyten bilden während der Phagozytose das toxische Superoxid-Radikal (O −2 ). Das kupferhaltige Enzym Superoxid Dismutase schützt intrazellulär vor der toxischen Wirkung des O −2 . Um die Rolle von O −2 und SOD im Rahmen der rheumatoiden Erkrankung zu untersuchen, wurde die O −2 -Bildung von Granulozyten und deren SOD-Aktivität bestimmt. Die SOD-Aktivität war im Vergleich mit Gesunden in Granulozyten von Kindern mit rheumatischen Erkrankungen deutlich erniedrigt. Nach Stimulation mit opsoniertem Zymosan bildeten die Granulozyten von Kindern mit rheumatischen Erkrankungen mehr O −2 als Kontrollzellen. Der SOD-Mangel in Granulozyten von Kindern mit rheumatischen Erkrankungen begünstigt möglicherweise das vermehrte Auftreten toxischer Sauerstoffmetabolite im extrazellulären Raum, die eine rheumatische Gewebsschädigung verursachen können. Die Bedeutung der Superoxid-Dismutase und Superoxid-Radikal-Freisetzung im Rahmen rheumatischer Entzündungen sollte nicht nur zum Verständnis des Entzündungsgeschehens beitragen, sondern auch neue therapeutische Prinzipien unterstützen.

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Authors and Affiliations

  1. Universitäts-Kinderklinik Köln, Germany

    M. Rister & K. Bauermeister

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  1. M. Rister
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  2. K. Bauermeister
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Mit Unterstützung der Deutschen Forschungsgemeinschaft (RI 275/5) und der Stiftung Volkswagenwerk

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Rister, M., Bauermeister, K. Superoxid-Dismutase und Superoxid-Radikal-Freisetzung bei juveniler rheumatoider Arthritis. Klin Wochenschr 60, 561–565 (1982). https://doi.org/10.1007/BF01724212

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  • DOI: https://doi.org/10.1007/BF01724212

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