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The non-teratogenicity of 2,4,5-trichlorophenoxyacetic acid in the rhesus monkey (macaca mulatta)

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Summary

The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) containing 0.05 ppm of tetrachlorodibenzo-p-dioxin, was administered to pregnant rhesus monkeys daily from Day 22 through Day 38 of gestation. At the dose levels administered, 0.05 mg/kg, 1 mg/kg, and 10 mg/kg, no evidence of toxicity was seen in the mother and no evidence of teratogenicity was seen in any of the offspring. Observations of the infants for 1 year following birth indicated that there was no toxicity due to the 2,4,5-T.

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Authors and Affiliations

  1. International Center of Environmental Safety, Albany Medical College, P.O. Box 1027, 88330, Holloman AFB, N.M.

    William J. Dougherty

  2. C. O. Boehringer Sohn Department of Experimental Pathology and Toxicology, 6507, Ingelheim, Germany

    Manfred Herbst

  3. Institute of Comparative and Human Toxicology, Albany Medical College, 47 New Scotland Avenue, 12208, Albany, N.Y.

    Frederick Coulston

Authors
  1. William J. Dougherty
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  2. Manfred Herbst
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  3. Frederick Coulston
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Additional information

Supported by the C. H. Boehringer Sohn, Ingelheim/Rh, Germany; and Dow Chemical U.S.A., Midland, Michigan 48640

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Dougherty, W.J., Herbst, M. & Coulston, F. The non-teratogenicity of 2,4,5-trichlorophenoxyacetic acid in the rhesus monkey (macaca mulatta). Bull. Environ. Contam. Toxicol. 13, 477–482 (1975). https://doi.org/10.1007/BF01721855

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  • DOI: https://doi.org/10.1007/BF01721855

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