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Plasmalipoproteine bei Störungen der Schilddrüsenfunktion des Menschen

Concentrations of the main lipoprotein density classes in disturbances of thyroid function in man

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Summary

The concentration of the main lipoprotein density classes and the postheparin lipolytic activity (PHLA) were determined in the plasma of 12 hyperthyroid and eight hypothroid patients in comparison with 12 euthyroid, metabolically healthy individuals. Low-density lipoproteins (LDL) and high-density lipoproteins2 (HDL2) were decreased in hyperthyreosis (p<0.01) and increased in hypothyreosis (p<0.01). No significant differences could be detected with respect to the concentration of very low-density lipoproteins (VLDL) as well as for HDL3, whereas intermediate-density lipoproteins (IDL) were higher in hypothyreotics than in controls (p<0.05). PHLA was increased in hyperthyreosis (p<0.01) and decreased in hypothyreosis (p<0.01). The chemical composition of LDL and HDL2 as well as the apolipoprotein composition of the protein moiety of HDL2 in hyperthyreosis and in hypothyreosis did not significantly differ from those in the control group. When data from all individuals studied were analyzed, no significant relationship could be detected between the concentrations of VLDL and HDL2, whereas HDL2 and PHLA correlated in a negative manner (p<0.05). It is suggested that HDL2, in addition to LDL, acts as carrier protein for the cholesterol increasingly yielded in hypothyreosis.

Zusammenfassung

Die Konzentration der Hauptlipoproteindichteklassen und die Post-heparin-lipolytische Aktivität (PHLA) wurden im Plasma von 12 hyperthyreoten und 8 hypothyreoten Patienten im Vergleich mit 12 euthyreoten, stoffwechselgesunden Kontrollpersonen bestimmt. Low-density-lipoproteins (LDL) und high-density lipoproteins2 (HDL2) waren bei Hyperthyreose erniedrigt (p<0,01) und bei Hypothyreose erhöht (p<0,01). Im Hinblick auf die Konzentration der very-low-density-lipoproteins (VLDL) und der HDL3 bestanden keine signifikanten Unterschiede, während die intermediate-density-lipoproteins (IDL) bei hypothyreoten Patienten erhöht waren (p<0,05). Die PHLA war bei Hyperthyreose erhöht (p<0,01) und bei Hypothyreose erniedrigt (p<0,01). Die chemische Zusammensetzung der LDL und HDL2 von Patienten mit Hyper- und Hypothyreose sowie die Apolipoproteinzusammensetzung des Proteinanteils der HDL2 unterschieden sich nicht signifikant von denen der Kontrollen. Bei Analyse der Daten aller untersuchten Individuen ergab sich keine signifikante Beziehung zwischen VLDL und HDL2, während HDL2 und PHLA signifikant negativ korrelierten (p<0,05). Es wird vermutet, daß HDL2 zusätzlich zu den LDL als Träger des bei der Hypothyreose vermehrt vorhandenen Cholesterins fungieren.

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Authors and Affiliations

  1. Universitätsklinik für Innere Medizin, Anichstraße 35, A-6020, Innsbruck, Österrieich

    H. J. Lisch, M. Ogriseg, Ch. Breier, H. Drexel, H. Fill & S. Sailer

  2. Universitätsklinik für Nuklearmedizin, Innsbruck

    H. J. Lisch, M. Ogriseg, Ch. Breier, H. Drexel, H. Fill & S. Sailer

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  1. H. J. Lisch
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  2. M. Ogriseg
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  3. Ch. Breier
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  4. H. Drexel
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  5. H. Fill
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  6. S. Sailer
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Lisch, H.J., Ogriseg, M., Breier, C. et al. Plasmalipoproteine bei Störungen der Schilddrüsenfunktion des Menschen. Klin Wochenschr 60, 337–342 (1982). https://doi.org/10.1007/BF01721623

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  • DOI: https://doi.org/10.1007/BF01721623

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