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Elevated angiotensin-i-converting enzyme (ACE) in patients with essential hypertension

Erhöhtes Angiotensin-I-Converting Enzym (ACE) bei Patienten mit essentieller Hypertonie

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Summary

We investigated the alteration of the ACE in different parts of the circulation in 21 patients with essential hypertension, who suffered from angina pectoris attacks. Blood samples were taken during diagnostic cardiac catheterisation. The ACE was fluorimetrically measured and compared to 48 normotensive patients. In 11 patients the Plasma Renin Activity (PRA) was additionally determined by means of bioassay. The ACE was significantly (p<0.001) elevated in all investigated regions but a different distribution was not observed. We found a positive correlation between the ACE from the left ventricle and the systolic, mean arterial and diastolic blood pressure. Furthermore we observed a negative correlation between ACE and PRA. No relationship could be calculated between ACE and electrolytes, creatinine or haemodynamic parameters. Our results indicate that the ACE may contribute to the pathogenesis of so-called essential hypertension.

Zusammenfassung

Wir untersuchten die Veränderungen des ACE in verschiedenen Gefäßregionen bei 21 essentiellen Hypertonikern, die wegen des Verdachts auf eine coronare Herzkrankheit coronarographiert wurden. Das ACE wurde mit Hilfe einer fluorimetrischen Mikromethode bestimmt. Bei 11 Patienten wurde zusätzlich die Plasma Renin Aktivität (PRA) mit einer biologischen Methode gemessen. Das ACE war in allen untersuchten Gefäßregionen im Vergleich zu 48 Normotonen signifikant (p<0,001) erhöht. Eine unterschiedliche Verteilung konnte nicht nachgewiesen werden. Wir fanden eine positive Korrelation zwischen dem ACE, gemessen im linken Ventrikel, und dem systolischen, diastolischen sowie dem arteriellen Mitteldruck. Außerdem zeigte sich eine negative Korrelation zwischen dem ACE und der PRA. Keine Beziehung konnte zwischen ACE und Elektrolyten, Kreatinin und hämodynamischen Parametern beobachtet werden. Wir vermuten, daß dem ACE bei der Pathogenese der sogenannten essentiellen Hypertonie eine Bedeutung zukommt.

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Authors and Affiliations

  1. Medizinische Universitätsklinik Würzburg, Germany

    H. Schweisfurth

  2. Medizinische Universitätsklinik I München, Germany

    A. Kment & B. E. Strauer

  3. Physiologisches Institut der Universität München, Germany

    H. Dahlheim

Authors
  1. H. Schweisfurth
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  2. A. Kment
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  3. H. Dahlheim
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  4. B. E. Strauer
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Schweisfurth, H., Kment, A., Dahlheim, H. et al. Elevated angiotensin-i-converting enzyme (ACE) in patients with essential hypertension. Klin Wochenschr 60, 49–50 (1982). https://doi.org/10.1007/BF01721587

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  • DOI: https://doi.org/10.1007/BF01721587

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