Summary
26 homosexual men with HIV-infection and lymphadenopathy syndrome were examined between 1982 and 1984 and prospectivelly observed over a period of 58 months (median, range 53–69 months). 16 (61.5%) developed full blown AIDS within a median period of 41 months (23–63 months). 12 of them died 50 months (median, range 29–67 months) after the first examination. 10 patients showed no symptoms of AIDS after a median observation time of 57 months (54–63 months). A panel of clinical symptoms, signs of concomitant infections, chemical and immunological analyses, including a lymphnode biopsy were correlated to the course of the disease. A decreased proportion of CD4-cells and a lower CD4/CD8ratio in the lymphnode suspensions at the first examination in patients with disease progression were the only parameter which correlated significantly with the development of AIDS.
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Abbreviations
- AIDS:
-
Acquired Immunodeficiency Syndrome
- CD:
-
Cluster of differentiation
- ConA:
-
Concanavalin A
- PHA:
-
Phythämagglutinin
- PWM:
-
Pokeweed Mitogen
Literatur
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Harrer, T., Messing, K., Bienzle, U. et al. Manifestation von AIDS in HIV-infizierten homosexuellen Männern mit Lymphadenopathie-Syndrom (LAS). Klin Wochenschr 67, 936–939 (1989). https://doi.org/10.1007/BF01721419
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DOI: https://doi.org/10.1007/BF01721419