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European Journal of Epidemiology

, Volume 11, Issue 4, pp 397–402 | Cite as

An epidemic of hepatitis B virus infection among intravenous drug users in Iceland

  • Arthur Löve
  • Barbara Stanzeit
Article

Abstract

This study describes an outbreak of hepatitis B primarily among intravenous drug users in Iceland which has a population with a very low incidence of hepatitis B virus infection. The incidence of acute hepatitis B is generally low in the Nordic Countries, in the order of one to five cases per 100,000 people per year. Between 1989 and 1992 there was an outbreak of hepatitis B virus infection primarily among the intravenous drug user (IVDU) population in Iceland. At the Department of Medical Virology, University of Iceland there were 44 cases of acute hepatitis B identified during the peak year 1990, an incidence of 16.9 cases of acute hepatitis B per 100,000 people. 63.6% of these were known to be IVDUs. The seroprevalence of the hepatitis B core antibody (anti-HBc) marker was assessed among 1100 randomly selected individuals. The average prevalence of this marker was 2.9% and rose from zero at the age of 15 and younger to 6.5% at the age of 65 and older. Among IVDUs attending a detoxification clinic in 1990 the prevalence of the anti-HBc was 32%. In contrast, those attending the same clinic, due to alcoholism only, did not have a significantly higher prevalence of anti-HBc than the group used for comparison.

Key words

Epidemiology Hepatitis B virus Incidence Intravenous drug users Prevalence 

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References

  1. 1.
    Iwarson S, Lindholm A, Lundin P, Hermodsson S. Hepatitis-associated antigen and antibody in Swedish blood donors. Vox Sang 1972; 22: 501–509.Google Scholar
  2. 2.
    Solaas MH. Frequency of the Australia-SH antigen and antibody among Norwegian blood donors. Scand J Haematol 1970; 7: 506–508.Google Scholar
  3. 3.
    Banke O, Dybkjaer E, Nordenfelt E, Reinicke V. Australia-antigen and antibody in 10000 Danish blood donors. Lancet 1971 (i): 860–861.Google Scholar
  4. 4.
    Helske T. Carriers of hepatitis B antigen and transfusion hepatitis in Finland. Scand J Haematol 1974; (suppl) 22.Google Scholar
  5. 5.
    Sobeslavsky O. Prevalence of markers of hepatitis B virus infection in various countries: A WHO collaborative study. Bull WHO 1980; 58: 621–628.Google Scholar
  6. 6.
    Guðmundsson S, Jensson Ó. Leit ad lifrarb ólguveiru B hjá blódgjöfum. Icel Med J 1978; 64: 91–95.Google Scholar
  7. 7.
    Jónasson JL. Hepatitis B antigen. Icel Med J 1977; 63: 3–17.Google Scholar
  8. 8.
    Sigfússon N. Hypertension in middle-aged men: The effect of repeated screening and referral to community physicians on hypertension control. Acta Med Scand 1986; Suppl. 710: 1–131.Google Scholar
  9. 9.
    Soka RR, Rohlf FJ. Biometry, 2nd ed. New York: W.H. Freeman and Company, 1981.Google Scholar
  10. 10.
    Remington RD, Schork MA. Statistics with application to the biological and health sciences, 2nd ed. New Jersey: Prentice Hall, 1985.Google Scholar
  11. 11.
    Christenson B. Epidemiology of hepatitis B in Sweden. J Infect 1987; 15: 269–277.Google Scholar
  12. 12.
    Iwarson S, Jilg W, Stroffolini T. Substantial decline of notified hepatitis B in major parts of Europe after 1985. Scand J Infect Dis 1994; 26: 19–22.Google Scholar
  13. 13.
    Gade K. Hepatitis B 1991–1992. Copenhagen, Denmark: Epi-Nyt. Statens Seruminstitut; 18 November 1993.Google Scholar
  14. 14.
    Alter MJ, Hadler SC, Margolis HS, Alexander J, Hu PY, Judson FN, Mares A, Miller JK, Mayer LA. The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies. JAMA 1990; 263: 1218–1222.Google Scholar
  15. 15.
    Public Health in Iceland. Surgeon General's Office, 1984–1985. Reykjavik, Iceland.Google Scholar
  16. 16.
    Baxter DN, Moran A. Acute hepatitis B infection in Stockport during 1984 and 1985. Community Med 1988; 10: 298–305.Google Scholar
  17. 17.
    McQuillan GM, Townsend TR, Fields HA, Carroll M, Leahy M, Polk BF. Seroepidemiology of hepatitis B virus infection in the United States. Am J Med 1989; 87 (suppl 3A): 5s-10s.Google Scholar
  18. 18.
    Hollinger FB. Hepatitis B virus. In: Fields BN, Knipe MD (eds), Virology, 2nd edition. New York: Raven Press, 1990: 2171–2236.Google Scholar
  19. 19.
    Rodriguez MA, Ceuppens JL, Goodwin JS. Regulation of IgM rheumatoid factor production in lymphocyte cultures from young and old subjects. J Immunol 1982; 128: 2422–2428.Google Scholar
  20. 20.
    Vejtorp M. The interference of IgM rheumatoid factor in enzyme-linked immunosorbent assays of rubella IgM and IgG antibodies. J Virol Meth 1980; 1: 1–9.Google Scholar
  21. 21.
    Struve J, Giesecke J, Olcen P, von Sydow M, Weiland O. Prevalence of hepatitis B virus markers in Sweden: A community-based serosurvey of 4000 young Swedish adults. Am J Epidemiol 1992; 135 (4): 409–417.Google Scholar
  22. 22.
    Burgess MA, McIntosh ED, Allars HM, Kenrick KG. Hepatitis B in urban Australian schoolchildren: No evidence of horizontal transmission between high-risk and low-risk groups. Med J Aust 1993; 159: 315–319.Google Scholar
  23. 23.
    Hurie MB, Mast EE, Davis JP. Horizontal transmission of hepatitis B virus infection to United States born children of Hmong refugees. Pediatrics 1992; 89: 269–273.Google Scholar

Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Arthur Löve
    • 1
  • Barbara Stanzeit
    • 1
  1. 1.Department of Medical VirologyUniversity of Iceland128 ReykjavíkIceland

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