Klinische Wochenschrift

, Volume 60, Issue 23, pp 1465–1472 | Cite as

Klinische Wertigkeit der Bestimmung zirkulierender Immunkomplexe bei Patientinnen mit metastasierendem Mammakarzinom

  • G. Krieger
  • A. Kehl
  • I. Bause
  • M. Kneba
  • G. A. Nagel

Clinical significance of circulating immune complexes in patients with metastatic breast cancer


In 68 patients with metastatic breast cancer a follow-up study was performed to correlate circulating immune complexes (CIC) as detected by the C1q binding assay and the Raji cell radio immunoassay with the state of disease. Clinical examinations and determinations of CIC were carried out all four to eight weeks over at least six months. 19 patients were positive for CIC in the C1q binding assay and 12 in the Raji cell radio-immunoassay. There was no correlation between the results of both tests. In comparison 26 patients out of 68 with rheumatoid arthritis were positive in the C1q binding assay and 32 in the Raji cell assay. In these patients the results of both tests correlated significantly.

There was only in a few cases of metastatic breast cancer a positive correlation between levels of CIC and changes of tumor burden. Furthermore, CIC did not prove to be of prognostic value.

Key words

Breast cancer Immune complexes 


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  1. 1.
    Agnello V (1981) Immune complex assays: the first ten years. Ann Intern Med 94:266–267Google Scholar
  2. 2.
    Carpentier N, Chollet P, Betail G, Plaque R, Lambert PH (1980) Immune complexes: escape mechanism of tumor cell in breast cancer? 4th International Congress of Immunology, Paris, July 1980, Abstract 10.306Google Scholar
  3. 3.
    Chapuis B, Lous I, Barrelet L, Dialdas I, Dragon V, Cerottini I-C (1980) Complexes antigène-anticorps circulants et cancer. Schw Med Wochenschr 110:796–801Google Scholar
  4. 4.
    Jenette ICh, Feldman ID (1977) Sequential quantitation of circulating immune complexes in syngeneic and allogeneic rats bearing Moloney sarcomas. J Immunol 118:2269–2274Google Scholar
  5. 5.
    Heier HE, Carpentier N, Lange G, Lambert P-H, Godal T (1977) Circulating immune complexes in patients with malignant lymphomas and solid tumors. Int J Cancer 20:887–894Google Scholar
  6. 6.
    Hellström KE, Hellström I, Nepom IT (1977) Specific blocking factors — are they important? Biochim Biophys Acta 473:121–148Google Scholar
  7. 7.
    Herbermann RB, Bordes M, Lambert PH, Luthra HJ, Robins RA, Jizaret P, Theofilopoulos A (1981) Report on international comparative evaluation of possible value of assays for immune complexes for diagnosis of human breast cancer. Int J Cancer 27:569–576Google Scholar
  8. 8.
    Höffken K, Schmidt CG (1980) Immunkomplexe bei malignen Erkrankungen: Tumormarker oder Epiphaenomen? Dtsch Med Wochenschr 105:1697–1699Google Scholar
  9. 9.
    Höffken K, Meredith ID, Robins RA, Baldwin RW, Davies CJ, Blamey RW (1978) Immune complexes and prognosis of human breast cancer. Lancet 1:672–673Google Scholar
  10. 10.
    Koestler ThP, Papsidero LD, Nemoto T, Chu TM (1981) Detection of a breast tissue-associated antigen by antiserum to Raji cellbound circulating immune complexes of human breast cancer. Cancer Res 41:2900–2907Google Scholar
  11. 11.
    Lambert PH, Dixon FJ, Zubler RH, Agnello V, Cambiaso C et al. (1978) A WHO collaborative study for the evaluation of eighteen methods for detecting immune complexes in serum. J Clin Lab Immunol 1:1–15Google Scholar
  12. 12.
    Nagel GA, Wander HE (1981) Metastasierende Mammakarzinome: Therapieplanung unter Berücksichtigung von Prognosefaktoren. Dtsch Ärztebl 9:399–402Google Scholar
  13. 13.
    Papsidero LD, Nemoto T, Snydermann MC, Chu TM (1979) Immune complexes in breast cancer patients as detected by C1q binding. Cancer 44:1636–1640Google Scholar
  14. 14.
    Rossen RD, Reisberg MA, Hersh EM, Gutterman JU (1977) The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer. J Natl Cancer Inst 58:1205–1215Google Scholar
  15. 15.
    Theofilopoulos AN, Wilson CB, Dixon FI (1976) The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest 57:169–182Google Scholar
  16. 16.
    Theofilopoulos AN, Dixon FI (1980) Immune complexes associated with neoplasia. In: Herberman RB, McIntire KR (eds) Immunodiagnosis of cancer, part 2. Marcel Dekker, New York Basel, pp 896–937Google Scholar
  17. 17.
    World Health Organization, Handbook for reporting results of cancer treatment (1979) WHO Offset Publication No 48, Geneva, p 45Google Scholar
  18. 18.
    Zubler RH, Lange G, Lambert PH, Miescher PA (1976) Detection of immune complexes in unheated sera by a modified125J-C1q binding test. J Immunol 116:232–235Google Scholar

Copyright information

© Springer-Verlag 1982

Authors and Affiliations

  • G. Krieger
    • 1
  • A. Kehl
    • 1
  • I. Bause
    • 1
  • M. Kneba
    • 1
  • G. A. Nagel
    • 1
  1. 1.Abteilung Hämatologie/OnkologieMedizinische Universitätsklinik GöttingenGermany

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