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Serum-Sialyltransferase activity in cancer patients

Die Sialyltransferaseaktivität im Serum von Tumorpatienten

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Summary

Serum-sialyltransferase activity was measured in serum samples of 116 patients with malignant tumors of various origins and different clinical stages using asialo-fetuin as the acceptor and cytidine-5′-mono-phospho[14C]sialic acid as the donor. Only patients with metastatic tumors had significantly elevated serum-sialyltransferase levels. Increased enzyme activity was also associated with rheumatoid arthritis and with acute hepatitis, whereas no significant alteration of enzyme activity was observed in cystic fibrosis patients. In a group of tumor patients, various additional tumor markers were determined (carcinoembryonic antigen, alkaline phosphatase: Regan isoenzyme, creatinekinase: BB-isoenzyme, lactatedehydrogenase: isoenzyme 5) and the data compared to the clinical diagnoses. The sensitivity and specifity of serum-sialyltransferase as a tumor marker is assessed.

Zusammenfassung

Die Sialyltransferase-Aktivität wurde bei 116 Patienten mit Tumoren verschiedenen Ursprungs und unterschiedlicher klinischer Stadien im Serum bestimmt. Nur bei Patienten mit Metastasen fand sich eine signifikant erhöhte Serum-Sialyltransferase-Aktivität im Vergleich zum Normalkollektiv. Eine gesteigerte Enzymaktivität wurde aber auch bei Rheumatikern und Hepatitispatienten ermittelt, nicht dagegen bei an zystischer Fibrose erkrankten Kindern. Einige Serien von Tumorpatienten wurden zusätzlich auf andere Tumormarker hin untersucht (Carcinomembryonales Antigen, Alkalische Phosphatase: Regan-Isoenzym, Creatinkinase: BB-Isoenzym, Lactatdehydrogenase: Isoenzym 5), und die Ergebnisse mit den klinischen Diagnosen verglichen. Die Sensitivität und die Spezifität der Serum-Sialyltransferase als Tumormarker wird diskutiert.

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Authors and Affiliations

  1. Med. Univ.-Klinik, Domagkstr. 3, D-4400, Münster, Federal Republic of Germany

    P. -G. Berge, A. Wilhelm,  H. Schriewer & G. Wüst

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  1. P. -G. Berge
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  2. A. Wilhelm
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  3. H. Schriewer
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  4. G. Wüst
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Berge, P.G., Wilhelm, A., Schriewer, H. et al. Serum-Sialyltransferase activity in cancer patients. Klin Wochenschr 60, 445–449 (1982). https://doi.org/10.1007/BF01720358

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  • DOI: https://doi.org/10.1007/BF01720358

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