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, Volume 60, Issue 1, pp 41–47 | Cite as

Ferrokinetics and erythropoiesis in mice after long-term inhalation of benzene

  • J. Vácha
  • V. Znojil
  • H. J. Seidel
  • Edda Barthel
Original article

Summary

Ferrokinetics and erythropoiesis were examined in mice exposed for 6 or 7 weeks to an airborne concentration of 300 ppm of benzene, for 6 h per day, and 5 days per week. Ferrokinetic indicators showed only a slightly enhanced production of haeme and erythrocytes in the spleen (133% ± 18% and 122% ± 17%, respectively). Production did not change in the femoral marrow; a decline of CFU-C, BFU-E and especially CFU-E (34% ± 8%) took place there and a shift of cellularity into less mature developmental classes in the erythroblast compartment, without this compartment as a whole being damaged. The erythrocytes produced have an enhanced MCV (109% ± 0%) and MCH (109% ± 1%) with an unchanged MCHC; their concentration in blood sank to 87% ± 1%. The absolute reticulocyte count rose to 160% ± 16%.59Fe incorporation into the liver declined far below the level attributable to decreased accessibility of the tracer (84% ± 4%). A shortening of the life span of late erythroblasts and circulating erythrocytes was deduced from these findings and methodological problems related to some of the seemingly controversial findings are discussed.

Key words

BFU-E CFU-E Erythroblasts Ferrokinetics Erythropoiesis Benzene 

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • J. Vácha
    • 1
  • V. Znojil
    • 1
  • H. J. Seidel
    • 2
  • Edda Barthel
    • 2
  1. 1.Institute of BiophysicsCzechoslovak Academy of SciencesBrnoCzechoslovakia
  2. 2.Institute for Occupational and Social MedicineUniversity of Ulm, Oberer EselsbergUlm/DonauFederal Republic of Germany

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