A case-control study was conducted in Marseille (France) to investigate the relationship between usual diet and risk of gastric cancer. Patients with histologically confirmed gastric adenocarcinoma were identified in 8 major centres for gastric surgery. Controls were selected in specialized medical centres from patients undergoing functional reeducation for injuries or trauma, according to the age and sex distributions of the cases. The study involved 92 cases and 128 controls who were interviewed with a dietary history questionnaire on their usual diet during the year preceding first symptoms for cases, or preceding interview for controls. Odds ratios for specific foods were calculated after adjustment for age, sex, occupation and energy intake. A reduced risk was observed for consumption of raw vegetables (OR2: 0.55; OR3: 0.41 for the second and third tertiles, respectively), fresh fruit (OR2: 0.63; OR3: 0.50), vegetable oil (OR2: 0.60; OR3: 0.52), pasta and rice (OR2: 1.06; OR3: 0.50) whereas consumption of cakes and pastries (OR2: 1.02; OR3: 2.96), sugar and confectionery (OR2: 0.96; OR3: 1.68) was associated with an increased risk. An increased risk was found for intake of saturated fat (OR2: 1.49; OR3: 1.67), simple sugars (OR2: 1.18; OR3: 1.78) and calcium (OR2: 1.84; OR3: 2.57). A decreased risk was observed with intake of fiber (OR2: 0.49; OR3: 0.59), fibre from vegetables and fruit (OR2: 0.83; OR3: 0.53) and iron (OR2: 0.70; OR3: 0.41).
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Bjelke E. Epidemiologic studies of cancer of the stomach, colon and rectum: With special emphasis on the role of diet. Scand J Gastroenterol 1974; 9 (suppl. 31): 1–235.
Boeing H. Epidemiological research in stomach cancer: Progress over the last ten years. J Cancer Res Clin Oncol 1991; 117: 133–143.
Boeing H, Frentzel-Beyme R, Berger M, Berndt V, Görez W, Körner M, Lohmeier R, Menarcher A, Männi HFK, Menhardt M, Müller R, Ostermeier H, Paul F, Schwemmle K, Wagner KH, Wahrendorf J. Case-control study on stomach cancer in Germany. Int J Cancer 1991; 47: 858–864.
Breslow NW, Day NE. Statistical methods in cancer research, Vol. 1: The analysis of case-control studies (IARC Scientific Publications No. 32). Lyon: International Agency for Research on Cancer, 1980.
Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, Biserni R, Cipriani F, Cocco P, Giacosa A, Marubini E, Puntoni R, Vindigni C, Fraumeni J, Blot W. A case-control study of gastric cancer and diet in Italy. Int J Cancer 1989; 44: 611–616.
Buiatti E, Palli D, Decarli A, Amadori D, Avellini C, Bianchi S, Bonaguri C, Cipriani F, Cocco P, Giacosa A, Marubini E, Minacci C, Puntoni R, Russo A, Vindigni C, Fraumeni J, Blot W. A case-control study of gastric cancer and diet in Italy, II: Associations with nutrients. Int J Cancer 1990; 45: 896–901.
Coggon D, Barker DJ, Cole RB, Nelson M. Stomach cancer and food storage. J Natl Cancer Inst 1989; 81: 1178–1182.
Correa P. A human model of gastric carcinogenesis. Cancer Res 1988; 48: 3554–3560.
Correa P, Fontham E, Pickle LW, Chen V, Lin Y, Haenszel W. Dietary determinants of gastric cancer in South Louisiana inhabitants. J Natl Cancer Inst 1985; 75: 645–654.
Demirer T, Icli F, Uzunalimoglu O, Kucuk O. Diet and stomach cancer incidence: A case-control study in Turkey. Cancer 1990; 65: 2344–2348.
De Stefani E, Correa P, Fierro L, Carzoglio J, Deneo-Pellegrini H, Zavala D. Alcohol drinking and tobacco smoking in gastric cancer: A case-control study. Rev Epidemiol Santé Publ 1990; 38: 297–307.
Forman D. The etiology of gastric cancer. In: O'Neill IK, Chen J, Barsch H (eds), Relevance to human cancer of N-nitroso compounds (IARC Scientific Publications No. 105). Lyon: International Agency for Research on Cancer 1991: 22–31.
Forman D, Al-Dabbagh S, Doll R. Nitrates, nitrites and gastric cancer in Great Britain. Nature 1985; 313: 620–625.
González CA, Riboli E, Badosa J, Batiste E, Viver J, Cardona T, Pita S, Sanz JM, Torrent M. Nutritional factors and gastric cancer in Spain. Am J Epidemiol 1994; 139: 466–473.
Graham S, Scholz W, Martino P. Alimentary factors in the epidemiology of gastric cancer. Cancer 1972; 30: 927–928.
Graham S, Haughey B, Marshall J, Brasure J, Zielezney M, Freudenheim J, West D, Nolan J, Wilkinson G. Diet in the epidemiology of gastric cancer. Nutr Cancer 1990; 13: 19–34.
Hill C, Benhamou E, Doyon F, Flamant R. Evolution de la mortalité par cancer en France entre 1950 et 1985 (Statistique de Santé). Paris: Editions INSERM, 1989.
Howson CP, Hirayama T, Wynder EL. The decline in gastric cancer: Epidemiology of an unplanned triumph. Epidemiol Rev 1986; 8: 1–27.
Hu JG, Zhang SF, Jia EM, Wang QQ, Liu SD, Liu YY, Wu YP, Cheng YT. Diet and cancer of the stomach: A case-control study in China. Int J Cancer 1988; 41: 331–335.
Jedrychowski W, Wahrendorf J, Popiela T, Rachtan J. A case-control study of dietary factors and stomach cancer risk in Poland. Int J Cancer 1986; 37: 837–842.
Kono S, Ikeda M, Tokudome S, Kuratsune M. A case-control study of gastric cancer and diet in northern Kyushu, Japan. Jpn J Cancer Res 1988; 79: 1067–1074.
La Vecchia C, Negri E, Decarli A, D'Avanzo B, Franceschi S. A case-control study of diet and gastric cancer in northern Italy. Int J Cancer 1987; 40: 484–489.
Macquart-Moulin G, Riboli E, Cornée J, Charnay B, Berthezéne P, Day N. Case-control study on colorectal cancer and diet in Marseille. Int J Cancer 1986; 38: 183–191.
Macquart-Moulin G, Riboli E, Cornée J, Kaaks R, Berthezène P. Colorectal polyps and diet: A case-control study in Marseille. Int J Cancer 1987; 40: 179–188.
Ostrowski RZ, Josse MC. Les aliments: Tables des valeurs nutritives. Paris: Jacques Lanore, 1978.
Paul AA, Southgate DAT. McCance and Widdowson's the composition of foods. London: HMSO, 1978.
Péquignot G, Cubeau J. Enquêues méthodologiques comparant chez les mêmes sujets la consommation alimentaire apprécié par interrogatoire à la consommation mesurée par pesée. Rev Epid émiol Santé Publ, 1973; 21: 585–608.
Pobel D, Riboli E, Cornée J, Hémon B, Guyader M. Nitrosamine, nitrate and nitrite in relation to gastric cancer: A case-control study in Marseille, France. Eur J Epidemiol 1995; 11: 67–73.
Randoin L, Le Gallic P, Dupuis Y, Bernardin A. Tables de composition des aliments. Paris: Jacques Lanore, 1982.
Renaud S, Godsey F, Ortchanian E, Baudier F. Table de composition des aliments (INSERM Unité 63). Paris: Astra-Calvé, 1979.
Riboli E, Péquignot G, Repetto F, Axerio M, Raymond L, Boffetta P, Zubiri A, Del Moral A, Est ève J, Tuyns AJ. A comparative study of smoking, drinking and dietary habits in population samples in Italy, Spain, Switzerland and France, 1: Study design and dietary habits. Rev Epidemiol Santé Publ 1988; 36: 151–165.
Risch HE, Jain M, Choi NW, Fodor JG, Pfeiffer G, Howe GR, Harrison LW, Craib KJP, Miller AB. Dietary factors and the incidence of cancer of the stomach. Am J Epidemiol 1985; 122: 947–959.
Tomatis L, Aitio A, Day NE, Heseltine E, Kaldor J, Miller AB, Parkin DM, Riboli E (eds). Cancer: Causes, occurrence and control (IARC Scientific Publications No. 100). Lyon: International Agency for Research on Cancer, 1990.
Trichopoulos D, Ouranos G, Day NE, Tzonou A, Manousos O, Papadimitriou CH, Trichopoulou A. Diet and cancer of the stomach: A case-control study in Greece. Int J Cancer 1985; 36: 291–297.
Tuyns AJ. Salt and gastrointestinal cancer. Nutr Cancer 1988; 11: 229–232.
Tuyns AJ, Kaaks R, Haelterman M, Riboli R. Diet and gastric cancer: A case-control study in Belgium. Int J Cancer 1992; 51: 1–6.
Willett W, Stampfer M. Total energy intake: Implications for epidemiologic analyses. Am J Epidemiol 1986; 124: 17–27.
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Cornée, J., Pobel, D., Riboli, E. et al. A case-control study of gastric cancer and nutritional factors in Marseille, France. Eur J Epidemiol 11, 55–65 (1995). https://doi.org/10.1007/BF01719946