Elevated levels of plasma uric acid have been linked to increased risk of cardiovascular diseases and their complications. As dairy proteins have been found to decrease plasma uric acid without increasing glomerular filtration rate, a sample of postmenopausal women living in Montreal was studied to investigate the nature of this relationship. Participants (158 Roman Catholic nuns) were randomly assigned to one of two test diets for a period of four weeks: the dairy foods group (n=81) consumed approximately 30 grams of dairy protein daily and the dairy-free diet group (n=77) ate no dairy foods at all. Subjects completed two one-day food records, a core questionnaire and a dairy foods diet history; blood specimens were obtained, and blood pressure, height and weight were measured. Average nutrient intakes differed as a consequence of the test diets, with significantly greater intakes of protein, fat, saturated fat, monounsaturated fat, potassium and calcium (p<0.01) in the dairy group after the study period, and lower dietary levels of protein, cholesterol, calcium and retinol (p<0.01) in the dairy-free group. Plasma uric acid was unchanged after the dietary intervention in the dairy group, but increased by 7.8 µmol/1 (p=0.03) in subjects on the dairy-free diet; however, diastolic blood pressure decreased in response to calcium (β=−22.9, SE=10.0,p=0.02) among those whose diet included dairy foods. The study results suggest that proteins of dairy origin may play a role in stabilising or lowering plasma uric acid, and that calcium or other components found in milk products may also reduce diastolic blood pressure. While these findings have implications for dietary prevention to decrease cardiovascular risk in postmenopausal women, further investigations should examine these mechanisms in men over the age of 50 to ascertain whether a similar response would occur.
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Beard JT. Serum uric acid and coronary heart dieases. Am Heart J 1983; 106: 379–400.
Folsom AR, Li Y, Rao X, Cen R, Zhang K, Liu X, He L, Irving S, Dennis BH. Body mass, fat distribution and cardiovascular risk factors in a Jean population of south China. J Clin Epidem 1994; 47 (2): 173–181.
Garrel DR, Verdy M, PetitClerc C, Martin C, Brulé D, Hamet P. Milk- and soy-protein ingestion: Acute effect on serum uric acid concentration. Am J Clin Nutr 1992; 53: 665–669.
Goldfinger S, Klinenberg JR, Seegmiller JE. Renal retention of uric acid induced by infusion of betahydroxybutyrate and aceto-acetate. N Engl J Med 1965; 272: 351–355.
Hamet P, Mongeau E, Lambert J, Bellavance F, Daignault-Gé1inas M, Ledoux M, Whissell-Cambiotti L. Interactions among calcium, sodium and alcohol intake as determinants of blood pressure. Hypertension 1991; 17 (suppl 1): 150–154.
Health and Welfare Canada. Canadian Nutrient File. Bureau of Nutritional Sciences 1982. Health and Welfare Canada.
Ingram DD, Gillum RF. Leukocyte count and cardiovascular risk factors. J Nat Med Assoc 1992; 84 (12): 1041–1043.
Jones G, Lee K, Swaminathan R. Glomerular filtration response to acute protein load. Lancet 1985 (ii) (8459): 838.
Levine W, Dyer AR, Shekelle RB, Schoenberger JA, Stamler J. Serum uric acid and 11.5-year mortality of middle-aged women: Findings of the Chicago, Heart Association Detection Ppject in Industry. J Clin Epidemiol 1989; 42 (3): 257–267.
Lewis HB, Doisy EA. Studies in uric metabolism. I. The influence of high protein diets on the endogenous elimination J Biol Chem 1918; 36: 1–7.
Mensink RP, Stolwijk AM, Katan MB. Effect of a monounsaturated diet vs. a polyunsaturated fatty acid-enriched diet on blood pressure in normotensive women and men. Eur J Clin Invest 1990; 20: 463–469.
Modan M, Halkin H. Hyperinsulinemia or increased sympathetic drive as links for obesity and hypertension, Review. Diab Care 1991; 14(6); 470–487.
Munan L, Kelly A, PetitClerc C. Population serum urate levels and their correlates. Am J Epidem 1976; 103 (4): 369–382.
Perloff D, Grim C, Flack J, et al. Human blood pressure determination by sphygmomanometry. Circulation 1993; 88: 2460–2470.
Persky VW, Dyer AR, Idris-Soven, et al. Uric acid: A risk factor for coronary heart disease? Circulation 1979; 59: 969–977.
Puig JG, Miranda ME, Mateos FA, Picazo ML, Jimenez ML, Calvin TS, Gil AA. Heredity nephropathy associated with hyperuricemia and gout. Arch Int Med 1993; 153 (3): 357–365.
Selby JV, Friedman GD, Quesenberry Jr, CP. The precursors of essential hypertension: Pulmonary function, heart, rate, uric acid, serum cholesterol and other serum chemistries. Am J Epidem 1990; 131 (6): 1017–1027.
Slot O. Hyperuricemia: Review. Ugeskrift for Laeger 1994; 156 (16): 2396–2401 (English abstract).
Spyckerelle Y, Steinmetz J, Deschamps JP. Comparaison à cinq ans d'intervalle des taux de cholesterol, glucose et acide urique chez l'enfant et l'adolescent. Arch Franc de Pédiatrie 1992; 49 (10): 875–881. 281
Van Beresteijin ECH, Van Schaik M, Schaafsam G. Milk: Does it affect blood pressure? A controlled intervention study. J Intern Med 1990; 228: 477–482.
Verdy M, Blanchard D, St-Onge M, Nadeau M, Gutkowska J, Hamet P, PetitClerc C. Glomerular filtration response to an acute casein load in normal subjects. Clin Biochem 1987; 20: 288 (abstract).
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Ghadirian, P., Shatenstein, B., Verdy, M. et al. The influence of dairy products on plasma uric acid in women. Eur J Epidemiol 11, 275–281 (1995). https://doi.org/10.1007/BF01719431
- Cardiovascular disease
- Dietary protein
- Dairy products
- Uric acid