Summary
B-cell epitopes of varicella-zoster virus glycoprotein II were mapped by means of solid phase ELISA, synthetic oligopeptides (constructed according to the Davison-Scott sequencing of the varicella-zoster virus genome) and sera from varicellae and herpes zoster patients. The individual pattern of antibody peptide binding varied considerably but at least 9 more reactive sites seemed discernible. A 31-mer-peptide corresponding to a hydrophilic segment of the glycoprotein (aa 417–447) was constructed. This peptide reacted with 2 out of 4 varicellae and 5 out of 9 zoster sera, respectively.
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References
Bergström T, Lycke E (1990) Neuroinvasion by herpes simplex virus. An in vitro model for characterization of neurovirulent strains. J Gen Virol 71: 405–410
Bergström T, Sjögren-Jansson E, Jeansson S, Lycke E (1992) Mapping neuroinvasiveness of the herpes simplex virus type 1 encephalitis-inducing strain 2762 by the use of monoclonal antibodies. Mol Cell Probes 6: 41–49
Davison A, Scott JE (1986) The complete DNA sequence of varicella-zoster virus. J Gen Virol 67: 1 759–1 816
Grose C (1990) Glycoproteins encoded by varicella-zoster virus: biosynthesis, phosphorylation, and intracellular trafficking. Annu Rev Microbiol 44: 59–80
Grose C (1991) Glycoproteins of varicella-zoster virus and their herpes simplex homologs. Rev Infect Dis 13 [Suppl 11]: 960–963
Hayward A (1990) T-cell responses to predicted amphipathic peptides of varicella-zoster virus glycoproteins II and IV. J Virol 64: 651–655
Junker A, Tilley P (1994) Varicella-zoster virus antibody avidity and IgG-subclass patterns in children with recurrent chickenpox. J Med Virol 43: 119–124
Keller PM, Davison AJ, Lowe RS, Bennett CD, Ellis RW (1986) Identification and structure of the gene encoding gpII, a major glycoprotein of varicella-zoster virus. Virology 152: 181–191
Manservigi R, Cassai E (1991) The glycoproteins of the human herpesviruses. Comp Immunol Microbiol Infect Dis 14: 81–95
Massaer M, Haumont M, Place M, Bollen A, Jacobs P (1993) Induction of neutralizing antibodies by varicella-zoster virus gpII glycoprotein expressed from recombinant vaccinia virus. J Gen Virol 74: 491–494
Sundqvist V-A, Linde A, Wahren B (1984) Virus-specific immunoglobulin G subclasses in herpes simplex and varicella-zoster virus infections. J Clin Microbiol 20: 94–98
Weise K, Kaerner HC, Glorioso J, Schröder CH (1987) Replacement of glycoprotein B sequences in herpes simplex virus type 1 strain ANG by corresponding sequences of the strain KOS causes changes in plaque morphology and neuropathogenicity. J Gen Virol 68: 1 909–1 919
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Kjartansdóttir, A., Lycke, E. & Norrby, S.R. B-cell epitopes of varicella-zoster virus glycoprotein II. Archives of Virology 141, 2465–2469 (1996). https://doi.org/10.1007/BF01718644
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DOI: https://doi.org/10.1007/BF01718644