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Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats

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Summary

To understand the mode of persistent infection of Seoul virus in rodents, we examined the distribution of the virus genome and antibody production in infected rats. When 1-day-old rats were inoculated with the KI-83-262 strain, the S segment of viral genome was detected in sera, clots, lungs and kidneys from 3 to 184 days post inoculation (d.p.i.) by nested reverse transcriptase PCR. On the other hand, when 7-week-old rats were infected with this virus, viral genome was detected only in the lungs from 3 to 50 d.p.i. The neutralizing antibody titers of rats inoculated at 1-day of age were higher than those of rats inoculated at 7 weeks of age. In both age groups, however, the IgG avidity of antibody increased along with the course of infection. We found that urban rats (Rattus norvegicus) infected early in life harbored the virus for more than 6 months.

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Authors and Affiliations

  1. Laboratory of Public Health, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan

    H. Kariwa, M. Kimura, S. Yoshizumi, I. Takashima & N. Hashimoto

  2. Institute for Animal Experimentation, School of Medicine, Hokkaido University, Sapporo, Japan

    J. Arikawa & K. Yoshimatsu

  3. Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical Center, 35 Lake Avenue North, 01655, Worcester, MA, USA

    H. Kariwa

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  1. H. Kariwa
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  2. M. Kimura
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  3. S. Yoshizumi
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  4. J. Arikawa
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  5. K. Yoshimatsu
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  6. I. Takashima
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  7. N. Hashimoto
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Kariwa, H., Kimura, M., Yoshizumi, S. et al. Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats. Archives of Virology 141, 2327–2338 (1996). https://doi.org/10.1007/BF01718634

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  • DOI: https://doi.org/10.1007/BF01718634

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