Archives of Virology

, Volume 141, Issue 1, pp 167–175 | Cite as

Evidence for involvement of equine herpesvirus 1 glycoprotein B in cell-cell fusion

  • J. E. Wellington
  • D. N. Love
  • J. M. Whalley
Brief Report

Summary

Monoclonal antibodies specific for equine herpesvirus 1 (EHV-1) glycoproteins (gB, gD, gp2 and a cleaved translation product of gene 71) were tested for ability to inhibit cell-cell fusion as measured by syncytium formation in EHV-1 infected cell cultures. Syncytium formation was inhibited by a complement-dependent neutralising antibody (7B10) which recognised the large subunit of EHV-1 gB. This indicated that EHV-1 gB, in common with gB homologues of herpes simplex virus and other herpesviruses, plays a role in the cell-cell fusion process.

Keywords

Cell Culture Monoclonal Antibody Infectious Disease Infected Cell Herpes Simplex 

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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • J. E. Wellington
    • 1
  • D. N. Love
    • 2
  • J. M. Whalley
    • 1
  1. 1.School of Biological SciencesMacquarie UniversitySydney
  2. 2.Department of Veterinary PathologyUniversity of SydneyAustralia

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