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Alternation of interleukin-1α production and interleukin-1α binding sites in mouse brain during rabies infection

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Summary

We have evaluated the effect of rabies virus infection on interleukin-1α(IL-1α) production and its receptors in mouse brain. Study of virus dissemination in the central nervous system (CNS) showed a massive infection of main brain structures from day 4 post infection (p.i.) up to the agony stage on day 6 p.i. At the same time, IL-1α concentrations increased in cortical and hippocampal homogenates, whereas no change was detected in serum. In non-infected mice, IL-1α binding sites were observed in the dentate gyrus, the cortex, the choroid plexus, the meninges and the anterior pituitary. During rabies virus infection, a striking decrease in IL-1α binding sites was observed on day 4 p.i. with a complete disappearance on day 6 p.i., except in the pituitary gland where they remained at control level. In conclusion, concomitantly with the early rabid pathological signs, brain IL-1α production and IL-1α binding sites are specifically and significantly altered by brain viral proliferation. These results indicate that IL-1α could be involved in the brain response to viral infection as a mediator and could participate in the genesis of the rabies pathogeny.

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Authors and Affiliations

  1. Rabies Unit, Pasteur Institute, Paris Cedex, France

    C. Marquette, P. -E. Ceccaldi, P. Weber & H. Tsiang

  2. Pharmacology Neuro-Immuno-Endocrine Unit, Pasteur Institute, Paris Cedex, France

    C. Marquette, E. Ban & F. Haour

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  1. C. Marquette
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  2. P. -E. Ceccaldi
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  3. E. Ban
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Marquette, C., Ceccaldi, P.E., Ban, E. et al. Alternation of interleukin-1α production and interleukin-1α binding sites in mouse brain during rabies infection. Archives of Virology 141, 573–585 (1996). https://doi.org/10.1007/BF01718318

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  • DOI: https://doi.org/10.1007/BF01718318

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