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Akute interstitielle Nephritis nach Piperacillin

Acute interstitial nephritis after piperacillin treatment

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Summary

A 75-year-old woman developed fever, exanthema and nonoliguric renal failure 16 days after the beginning of Piperacillin treatment. Renal biopsy revealed lympho-plasmacellular acute interstitial nephritis (AIN). A lymphocyte-transformation-test showed significant stimulation of patient's lymphocytes by Piperacillin. Corticosteroid-therapy correlated to clinical and renal improvement. Nevertheless the patient died of foudroyant septicemia caused by E. coli. Our report describes the first immunologically documented case of AIN following Piperacillin treatment.

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Abbreviations

SMP:

smooth muscle protein

PBC:

primary biliary cirrhosis

Ag:

Antigen

Ak:

Antikörper/Antibody

ANA:

antinukleäre Antikörper/antinuclear antibody

PEEP:

positive end-expiratory pressure

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Authors and Affiliations

  1. Medizinische Klinik A, Klinikum der Landeshauptstadt Wiesbaden, Germany

    O. Dörner & C. Piper

  2. Institut für Pathologie der Universität Mainz, Germany

    H. P. Dienes

  3. Medizinische Klinik II der Universität Tübingen, Germany

    P. A. Berg & H. v. Egidy

Authors
  1. O. Dörner
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  2. C. Piper
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  3. H. P. Dienes
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  4. P. A. Berg
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  5. H. v. Egidy
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Dörner, O., Piper, C., Dienes, H.P. et al. Akute interstitielle Nephritis nach Piperacillin. Klin Wochenschr 67, 682–686 (1989). https://doi.org/10.1007/BF01718030

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  • DOI: https://doi.org/10.1007/BF01718030

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