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Calcitonin gene products and the kidney

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Summary

Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation. Systemic infusion of CGRP and perfusion of isolated rat kidney reduces vascular resistance, and increases renal blood flow and glomerular filtration. CGRP stimulates renin secretion in vivo and in vitro and inhibits contraction of isolated rat mesangial cells by angiotensin II. Calcitonin does not affect vascular resistance, renal blood flow and glomerular filtration, and is less potent in stimulating renin secretion, and does not alter contraction of isolated rat mesangial cells by angiotensin II. CGRP also exerts renal tubular effects brought about probably through interaction with calcitonin receptors. To this end, increased excretion of sodium and chloride, and stimulation of urinary flow are less pronounced with CGRP than with calcitonin. Calcitonin, moreover, stimulates the fractional urinary excretion of calcium and phosphate.

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References

  1. Adelstein RS (1983) Regulation of contractile proteins by phosphorylation. J Clin Invest 72:1863–1866

    Google Scholar 

  2. Amann R, Skofitsch G, Lembeck F (1988) Species-related differences in the capsaicin-sensitive innervation of the rat and guinea-pig ureter. Naunyn-Schmiedeberg's Arch Pharmacol 338:407–410

    Google Scholar 

  3. Amara SG, Jonas V, Rosenfeld MG, Ong ES, Evans RM (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature 298:240–244

    Google Scholar 

  4. Amara SG, Arriza JL, Leff SE, Swanson LW, Evans RM, Rosenfeld MG (1985) Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin-gene related peptide. Science 229:1094–1097

    Google Scholar 

  5. Bauerfeind P, Hof R, Hof A, Cucala M, Sigrist S, von Ritter C, Fischer JA, Blum AL (1989) Distinct effects of human calcitonin gene-related peptides I and II on gastric blood flow and acid secretion in anesthetized rabbits. Amer J Physiol 256:G145-G149

    Google Scholar 

  6. Bijvoet OLM, Van Der Sluys Veer J, De Vries HR, Van Koppen ATJ (1971) Natriuretic effect of calcitonin in man. New Engl J Med 284:681–688

    Google Scholar 

  7. Born W, Rink H, Beglinger C, Fischer JA (1989) Differential regulation of secretion by calcium of the common region peptide of the calcitonin gene, calcitonin and calcitonin gene-related peptide in man. Program 71st Ann Meeting Endocrine Soc (abstract)

  8. Bouizar Z, Fouchereau-Peron M, Taboulet J, Moukthar S, Milhaud G (1986) Purification and characterization of calcitonin receptors in rat kidney membranes by covalent cross-linking techniques. Europ J Biochem 155:141–147

    Google Scholar 

  9. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene-related peptide is a potent vasodilator. Nature 313:54–56

    Google Scholar 

  10. Clementi G, Rapisarda E, Fiore CE, Prato A, Amico-Roxas M, Millia C, Bernardini R, Maugeri S, Scapagnini U (1986) Effects of salmon calcitonin on plasma renin activity and systolic blood pressure in the rat. Neurosci Lett 66:351–355

    Google Scholar 

  11. Diez-Guerra FJ, Zaidi M, Bevis P, MacIntyre I, Emson PC (1988) Evidence for release of calcitonin gene-related peptide and neurokinin A from sensory nerve endings in vivo. Neuroscience 25:839–846

    Google Scholar 

  12. Dotti-Sigrist S, Born W, Fischer JA (1988) Identification of a receptor for calcitonin gene-related peptides I and II in human cerebellum. Biochem Biophys Res Commun 151:1081–1087

    Google Scholar 

  13. Edvinsson L, Fredholm BB, Hamel E, Jansen I, Verrecchia C (1985) Perivascular peptides relax cerebral arteries concomitant with stimulation of cyclic adenosine monophosphate accumulation or release of an endothelium-derived relaxing factor in the rat. Neurosci Lett 58:213–217

    Google Scholar 

  14. Fischer JA, Born W (1987) Calcitonin gene products: evolution, expression and biological targets. Bone and Mineral 2:347–359

    Google Scholar 

  15. Fisher LA, Kikkawa DO, Rivier JE, Amara SG, Evans RM, Rosenfeld MG, Vale WW, Brown MR (1983) Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide. Nature 305:534–536

    Google Scholar 

  16. Foster GV, Baghdiantz A, Kumar MA, Slack E, Soliman HA, McIntyre (1964) Thyroid origin of calcitonin. Nature 202:1303–1305

    Google Scholar 

  17. Franco-Cereceda A, Gennari C, Nami R, Agnusdei D, Pernow J, Lundberg JM, Fischer JA (1987) Cardiovascular effects of calcitonin gene-related peptides I and II in man. Circul Res 60:393–397

    Google Scholar 

  18. Franco-Cereceda A, Henke H, Lundberg JM, Petermann JB, Hökfelt T, Fischer JA (1987) Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: Distribution and release by capsaicin. Peptides 8:399–410

    Google Scholar 

  19. Franco-Cereceda A, Lundberg JM, Saria A, Schreibmayer W, Tritthart HA (1988) Calcitonin gene-related peptide: release by capsaicin and prolongation of the action potential in the guinea-pig heart. Acta Physiol Scand 132:181–190

    Google Scholar 

  20. Ghatei MA, Gu J, Mulderry PK, Blank MA, Allen JM, Morrison JFB, Polak JM, Bloom SR (1985) Calcitonin gene-related peptide (CGRP) in the female rat urogenital tract. Peptides 6:809–815

    Google Scholar 

  21. Haas HG, Dambacher MA, Guncaga J, Lauffenburger T (1971) Renal effects of calcitonin and parathyroid extract in man. Studies in hypoparathyroidism. J Clin Invest 50:2689–2702

    Google Scholar 

  22. Haller-Brem S, Muff R, Petermann JB, Born W, Roos BA, Fischer JA (1987) Role of cytosolic free calcium concentration in the secretion of calcitonin gene-related peptide and calcitonin from medullary thyroid carcinoma cells. Endocrinology 121:1272–1277

    Google Scholar 

  23. Henke H, Sigrist S, Lang W, Schneider J, Fischer JA (1987) Comparison of binding sites for the calcitonin gene-related peptides I and II in man. Brain Res 410:404–408

    Google Scholar 

  24. Höppener JWM, Steenbergh PH, Slebos RJC, Visser A, Lips CJM, Jansz HS, Bechet JM, Lenoir GM, Born W, Haller-Brem S, Petermann JB, Fischer JA (1987) Expression of the second calcitonin/calcitonin gene-related peptide gene in Ewing sarcoma cell lines. J Clin Endocrinol Metab 64:809–817

    Google Scholar 

  25. Hua X-Y, Theodorsso-Norheim E, Lundberg JM, Kinn A-C, Hökfelt T, Cuello AC (1987) Co-localization of tachykinins and calcitonin gene-related peptide in capsaicinsensitive afferents in relation to motility effects on the human ureter in vitro. Neuroscience 23:693–703

    Google Scholar 

  26. Jaeger P, Jones W, Clemens TL, Hayslett JP (1986) Evidence that calcitonin stimulates 1,25-dihydroxyvitamin D production and intestinal absorption of calcium in vivo. J Clin Invest 78:456–461

    Google Scholar 

  27. Jonas V, Lin CR, Kawashima E, Semon D, Swanson LW, Mermod J-J, Evans RM, Rosenfeld MG (1985) Alternative RNA processing events in human calcitonin/calcitonin gene-related peptide gene expression. Proc Natl Acad Sci USA 82:1994–1998

    Google Scholar 

  28. Kubota M, Moseley JM, Butera L, Dusting GJ, MacDonald PS, Martin TJ (1985) Calcitonin gene-related peptide stimulates cyclic AMP formation in rat aortic smooth muscle cells. Biochem Biophys Res Commun 132:88–94

    Google Scholar 

  29. Kurtz A, Eckardt KU, Tannahill L, Bauer C (1988) Regulation of erythropoetin production. Contr Nephrol 66:1–16

    Google Scholar 

  30. Kurtz A, Muff R, Born W, Lundberg JM, Millberg B-I, Gnädinger MP, Uehlinger DE, Weidmann P, Hökfelt T, Fischer JA (1988) Calcitonin gene-related peptide is a stimulator of renin secretion. J Clin Invest 82:538–543

    Google Scholar 

  31. Kurtz A, Schurek HJ, Jelkmann W, Muff R, Lipp P, Fischer JA, Bauer C (1989) The renal mesangium is a target for calcitonin gene-related peptide. Kidney Intl (in press)

  32. Maggi CA, Giuliani S, Santicioli P, Abelli L, Meli A (1987) Visceromotor responses to calcitonin gene-related peptide (CGRP) in the rat lower urinary tract: evidence for a transmitter role in the capsaicin-sensitive nerves of the ureter. Europ J Pharmacol 143:73–82

    Google Scholar 

  33. Morel F (1983) Regulation of kidney functions by hormones: A new approach. In: Greep RO (ed) Recent Progress in Hormone Research, vol 39, Academic Press, New York, pp 271–304

    Google Scholar 

  34. Moseley JM, Findlay DM, Martin TJ, Gormann JJ (1982) Covalent crosslinking of a photoactive derivative of calcitonin to human breast cancer cell receptors. J Biol Chem 257:5846–5851

    Google Scholar 

  35. Petermann JB, Born W, Chang J-Y, Fischer JA (1987) Identification in the human central nervous system, pituitary, and thyroid of a novel calcitonin gene-related peptide, and partial amino acid sequence in the spinal cord. J Biol Chem 262:542–545

    Google Scholar 

  36. Reinecke M, Forsmann WG (1988) Neuropeptide (neuropeptide Y, neurotensin, vasoactive intestinal polypeptide, substance P, calcitonin gene-related peptide, somatostatin) immunohistochemistry and ultrastructure of renal nerves. Histochemistry 89:1–9

    Google Scholar 

  37. Roos BA, Bundy LL, Miller EA, Deftos LJ (1975) Calcitonin secretion by monolayer cultures of human C-cells from medullary thyroid carcinoma. Endocrinology 97:39–45

    Google Scholar 

  38. Roos BA, Fischer JA, Pignat W, Alander CB, Raisz LG (1986) Evaluation of the in vivo and in vitro calcium-regulating actions of noncalcitonin peptides produced via calcitonin gene expression. Endocrinology 118:46–51

    Google Scholar 

  39. Saria A, Gamse R, Petermann JB, Fischer JA, Theodorsson-Norhein E, Lundberg JM (1986) Simultaneous release of several tachykinins and calcitonin gene-related peptide from rat spinal cord slices. Neurosci Lett 63:310–314

    Google Scholar 

  40. Sexton PM, Adam WR, Moseley JM, Martin TJ, Mendelsohn FAO (1987) Localization and characterization of renal calcitonin receptors by in vitro autoradiography. Kidney Intl 32:862–868

    Google Scholar 

  41. Steenbergh PH, Höppener JWM, Zandberg J, Visser A, Lips CJM, Jansz HS (1986) Structure and expression of human calcitonin/CGRP genes. FEBS Lett 209:97–103

    Google Scholar 

  42. Tschopp FA, Tobler PH, Fischer JA (1984) Calcitonin generelated peptide in the human thyroid, pituitary and brain. Mol Cell Endocrinol 36:53–57

    Google Scholar 

  43. Tschopp FA, Henke H, Petermann JB, Tobler PH, Janzer R, Hökfelt T, Lundberg JM, Cuello C, Fischer JA (1985) Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary. Proc Natl Acad Sci USA 82:248–252

    Google Scholar 

  44. Villarreal D, Freeman RH, Verburg KM, Brands MW (1988) Renal hemodynamic response to intrarenal infusion of calcitonin gene-related peptide in dogs. Peptides 9:1129–1135

    Google Scholar 

  45. Villareal D, Freeman RH, Verburg KM, Brands MW (1988) Effects of calcitonin gene-related peptide on renal blood flow in the rat. Proc Soc Exp Biol Med 188:316–322

    Google Scholar 

  46. Wohlwend A, Malmström K, Henke H, Murer H, Vassalli J-D, Fischer JA (1985) Calcitonin and calcitonin gene-related peptide interact with the same receptor in cultured LLC-PK1 kidney cells. Biochem Biophys Res Commun 131:537–542

    Google Scholar 

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Authors and Affiliations

  1. Physiologic Institute, University of Zürich, Switzerland

    A. Kurtz

  2. Research Laboratory for Calcium Metabolism, Departments of Orthopedic Surgery and Medicine, University of Zürich, Zürich, Switzerland

    R. Muff & J. A. Fischer

  3. Klinik Balgrist, Forchstrasse 340, CH-8008, Zürich, Switzerland

    J. A. Fischer

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  2. R. Muff
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  3. J. A. Fischer
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Kurtz, A., Muff, R. & Fischer, J.A. Calcitonin gene products and the kidney. Klin Wochenschr 67, 870–875 (1989). https://doi.org/10.1007/BF01717342

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