Summary
Data from pharmacological studies carried out in healthy subjects using systemic histamine or impromidine and their antagonists are reviewed. Exogenous histamine by rapid injection appears to stimulate only H1-receptors. Chlorpheniramine alone antagonised the responses to histamine.
The effects of cardiovascular H2-receptor stimulation are demonstrated best by a sustained and large dose of histamine given by infusion. If it be considered desirable to antagonise all the cardiovascular responses to endogenous histamine, the available pharmacological data in man suggest this would be achieved best by a combination of an H1- and H2-receptor antagonist.
Zusammenfassung
Es wird über pharmakologische Studien an Probanden berichtet, wobei systemisch Histamin, Impromidin und ihre Antagonisten getestet wurden. Exogenes Histamin, welches durch schnelle Injektion appliziert wurde, scheint nur H1-Rezeptoren zu stimulieren, weil die Wirkungen des Histamins allein durch Chlorpheniramin antagonisiert werden können.
Die Effekte der kardiovaskulären H2-Rezeptorstimulation können am besten durch dauernde und hohe Dosen infundierten Histamins gezeigt werden. Sollen alle kardiovaskulären Reaktionen auf endogenes Histamin geblockt werden, so ergeben sich aufgrund der vorhandenen pharmakologischen Daten beim Menschen, daß diese am besten durch eine Kombination von H1- und H2-Rezeptorantagonisten erreicht werden können.
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Boyce, M.J. Pharmacological characterisation of cardiovascular histamine receptors in man in vivo. Klin Wochenschr 60, 978–982 (1982). https://doi.org/10.1007/BF01716958
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DOI: https://doi.org/10.1007/BF01716958